Latent transforming growth factor-beta: structural features and mechanisms of activation (Q28238140)

Europe PubMed Central

title

Latent transforming growth factor-beta: structural features and mechanisms of activation (English)

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author name string

J S Munger

1

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J G Harpel

2

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P E Gleizes

3

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R Mazzieri

4

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I Nunes

5

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D B Rifkin

The transforming growth factor-beta family

6

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language of work or name

English

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publication date

May 1997

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published in

Kidney International

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volume

51

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page(s)

1376-82

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issue

5

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cites work

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An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2

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Negative regulation of transforming growth factor-beta by the proteoglycan decorin

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Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system

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Protection of transforming growth factor-beta 1 activity by heparin and fucoidan

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Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice

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Transforming growth factor-beta activation in irradiated murine mammary gland

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Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system

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Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.

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Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1

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Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

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Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor

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Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin

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The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor

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The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

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Identification and analysis of discrete functional domains in the pro region of pre-pro-transforming growth factor beta 1.

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Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide

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Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium

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Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

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TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences

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Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

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Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3)

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Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

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Latent forms of transforming growth factor-beta (TGF beta) derived from bone cultures: identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGF beta

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Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix

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Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

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Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3

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Osteoclast synthesis and secretion and activation of latent transforming growth factor beta

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Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

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Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism

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Thrombospondins selectively activate one of the two latent forms of transforming growth factor-beta present in adrenocortical cell-conditioned medium

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Role for carbohydrate structures in TGF-beta 1 latency

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Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells

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7 January 2021

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes

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Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

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Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration

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7 January 2021

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells

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7 January 2021

Mechanism of retinoid-induced activation of latent transforming growth factor-? in bovine endothelial cells

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Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells

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Plasmin regulates the activation of cell-associated latent TGF-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury

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7 January 2021

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering

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Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells

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7 January 2021

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells

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7 January 2021

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta

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Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-beta bioactivity in mesangial cells

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PDGF and TGF-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products

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Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts

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Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity

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Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

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Transforming growth factor-beta1 is a mediator of androgen-regulated growth arrest in an androgen-responsive prostatic cancer cell line, LNCaP.

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7 January 2021

The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta

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7 January 2021

Vitamin D3 and calcipotriol enhance the secretion of transforming growth factor-beta 1 and -beta 2 in cultured murine keratinocytes

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7 January 2021

Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line

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7 January 2021

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

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7 January 2021

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

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7 January 2021