Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models (Q28239742)

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Erika A Scholl

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Brian D Klein

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Sean P Flynn

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Timothy H Pruess

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Brad R Green

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Liuyin Zhang

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Grzegorz Bulaj

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities

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language of work or name

English

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publication date

April 2009

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published in

Neurotherapeutics

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volume

6

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issue

2

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page(s)

372-80

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cites work

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First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

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Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

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Design and use of a new electroshock seizure apparatus, and analysis of factors altering seizure threshold and pattern

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A note on a simple apparatus for detecting neurological deficit in rats and mice

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Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury

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