Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head (Q28240099)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19339735%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head (English)

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25 January 2020

1

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25 January 2020

author name string

Anne-Marie Brun-Zinkernagel

series ordinal

2

1 reference

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25 January 2020

Abbot F Clark

series ordinal

3

1 reference

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25 January 2020

Robert J Wordinger

series ordinal

4

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25 January 2020

language of work or name

English

0 references

publication date

1 April 2009

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Investigative Ophthalmology Visual Science

25 January 2020

published in

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25 January 2020

volume

50

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25 January 2020

issue

12

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25 January 2020

page(s)

5759-5768

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19339735%20AND%20SRC:MED&resulttype=core&format=json

Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation

25 January 2020

cites work

1 reference

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Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix

20 March 2017

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Making sense of latent TGFbeta activation

20 March 2017

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Precursor convertases in the secretory pathway, cytosol and extracellular milieu

20 March 2017

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Regulation of cell survival by secreted proneurotrophins

20 March 2017

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Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes

20 March 2017

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The proprotein convertases furin and PACE4 play a significant role in tumor progression

20 March 2017

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

20 March 2017

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Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

20 March 2017

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Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

20 March 2017

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Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

20 March 2017

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PC8 [corrected], a new member of the convertase family

20 March 2017

1 reference

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Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms

20 March 2017

1 reference

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The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

20 March 2017

1 reference

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Processing of transforming growth factor beta 1 precursor by human furin convertase

20 March 2017

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Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases

20 March 2017

1 reference

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

20 March 2017

1 reference

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Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system

20 March 2017

1 reference

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Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

20 March 2017

1 reference

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The structure of the TGF-beta latency associated peptide region determines the ability of the proprotein convertase furin to cleave TGF-betas

29 September 2017

1 reference

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Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells.

29 September 2017

1 reference

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The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease

29 September 2017

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Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Proprotein convertases: "master switches" in the regulation of tumor growth and progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

29 September 2017

1 reference

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Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.

29 September 2017

1 reference

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Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model

29 September 2017

1 reference

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Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

29 September 2017

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Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection

29 September 2017

1 reference

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Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.

29 September 2017

1 reference

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Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases

29 September 2017

1 reference

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Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

29 September 2017

1 reference

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Polyarginines are potent furin inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The optic nerve head in glaucoma: role of astrocytes in tissue remodeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Neuroprotection in relation to retinal ischemia and relevance to glaucoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Transforming growth factor beta isoforms in human optic nerve heads

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

An endothelin-1 induced model of optic nerve ischemia in the rabbit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Eukaryotic protein processing: endoproteolysis of precursor proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The tissue distribution of mRNAs for the PACE4 isoforms, kexin-like processing protease: PACE4C and PACE4D mRNAs are major transcripts among PACE4 isoforms

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Cellular distributions of the prohormone processing enzymes PC1 and PC2.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Intracellular targeting and structural conservation of a prohormone-processing endoprotease.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Changes in the extracellular matrix of the human optic nerve head in primary open-angle glaucoma.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Optic nerve head extracellular matrix in primary optic atrophy and experimental glaucoma

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.

27 November 2018

1 reference

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Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Effect of exogenous neurotrophins on Trk receptor phosphorylation, cell proliferation, and neurotrophin secretion by cells isolated from the human lamina cribrosa.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Purification of astrocytes from adult human optic nerve heads by immunopanning

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Immunohistologic evidence for retinal glial cell changes in human glaucoma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Elevated furin expression in aggressive human head and neck tumors and tumor cell lines

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Astrocyte responses in human optic nerve head with primary open-angle glaucoma.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4155744

Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine

27 November 2018

1 reference

12 December 2020

Secretion of human furin into mouse milk

1 reference

12 December 2020

Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells

1 reference

12 December 2020

Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats

1 reference

12 December 2020

Increased NGF proforms in aged sympathetic neurons and their targets

1 reference

12 December 2020

Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma

1 reference

12 December 2020

Endothelin-1-mediated signaling in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in astrocytes

1 reference

12 December 2020

The mechanism of optic nerve damage in experimental acute intraocular pressure elevation

1 reference

12 December 2020

Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage

1 reference

12 December 2020

Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets

1 reference

12 December 2020

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

1 reference

12 December 2020

Identifiers

DOI

10.1167/IOVS.08-2616

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19339735%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19339735%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

19339735

1 reference