Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice (Q28240337)

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Christina Lynn Kiessel

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P Tarn Leach

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C Van Martin

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Rachel Lynn Karabenick

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X Chen

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Y Ohizumi

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Thomas Ullrich

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Kenner C Rice

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James H Woods

Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens

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language of work or name

English

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publication date

May 2004

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published in

Psychopharmacology

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volume

173

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issue

3-4

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page(s)

270-7

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cites work

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Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).

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Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor

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MDMA ('ecstasy') enhances basal acetylcholine release in brain slices of the rat striatum.

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Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat

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Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity

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The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

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Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (+/- )-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin

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Serotonergic receptor antagonist from Nandina domestica Thunberg

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A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors

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Structure-activity relationship on (+/-)-nantenine derivatives in antiserotonergic activities in rat aorta

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3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement

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Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat

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Correlations between different measures of antiserotonin activity of drugs. Study with neuroleptics and serotonin receptor blockers

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Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice

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Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

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Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats

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Do functional relationships exist between 5-HT1A and 5-HT2 receptors?

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The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist

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Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice

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Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

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Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice

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Two distinct central serotonin receptors with different physiological functions

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Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2 antagonist pirenperone

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In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

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In vitro dose dependent inverse effect of nantenine on synaptosomal membrane K+-p-NPPase activity

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Intravenous administration of ecstasy (3,4-methylendioxymethamphetamine) enhances cortical and striatal acetylcholine release in vivo

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