Signalling through the lipid products of phosphoinositide-3-OH kinase (Q28241516)

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

Europe PubMed Central

title

Signalling through the lipid products of phosphoinositide-3-OH kinase (English)

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author name string

A Toker

series ordinal

1

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L C Cantley

series ordinal

2

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language of work or name

English

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publication date

12 June 1997

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published in

Nature

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volume

387

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page(s)

673-6

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issue

6634

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cites work

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7 January 2021

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

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7 January 2021

PI3K: downstream AKTion blocks apoptosis

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7 January 2021

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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7 January 2021

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase

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7 January 2021

Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity

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7 January 2021

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

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7 January 2021

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

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7 January 2021

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

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7 January 2021

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

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7 January 2021

Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes

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7 January 2021

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase

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7 January 2021

Stimulation of an insulin receptor activates and down-regulates the Ca2+-independent protein kinase C, Apl II, through a Wortmannin-sensitive signaling pathway in Aplysia

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7 January 2021

Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase

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7 January 2021

Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptide

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7 January 2021

The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

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7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

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7 January 2021

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

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7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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7 January 2021

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

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7 January 2021

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

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7 January 2021

Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand

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7 January 2021

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

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7 January 2021

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

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7 January 2021

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

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7 January 2021

Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain

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7 January 2021

Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity

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7 January 2021

D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate

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7 January 2021

Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

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7 January 2021

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

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7 January 2021

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

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7 January 2021

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

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7 January 2021