Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module (Q28245104)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21823639%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module (English)

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9 February 2020

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4

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Christopher M Baxter Rath

9 February 2020

2

object named as

Christopher M Rath

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9 February 2020

author name string

Yousong Ding

1

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9 February 2020

Kyle L Bolduc

3

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9 February 2020

David H Sherman

5

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9 February 2020

language of work or name

English

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publication date

25 August 2011

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Journal of the American Chemical Society

9 February 2020

published in

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9 February 2020

volume

133

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9 February 2020

issue

37

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9 February 2020

page(s)

14492-14495

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GNAT-like strategy for polyketide chain initiation

9 February 2020

cites work

1 reference

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Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts

20 March 2017

1 reference

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Metamorphic enzyme assembly in polyketide diversification

20 March 2017

1 reference

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A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

29 September 2017

1 reference

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Chemoenzymatic synthesis of small molecule human therapeutics

29 September 2017

1 reference

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A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth

29 September 2017

1 reference

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Cloning and characterization of the biosynthetic gene cluster for kutznerides.

29 September 2017

1 reference

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Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry

29 September 2017

1 reference

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The stereochemistry of ketoreduction

29 September 2017

1 reference

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The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

The cryptophycins: their synthesis and anticancer activity

29 September 2017

1 reference

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

A family of drug transporters: the multidrug resistance-associated proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyldepsipeptide formation in Fusarium scirpi

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Chemoenzymatic synthesis of cryptophycin/arenastatin natural products

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Enantioselective synthesis of (+)-cryptophycin 52 (LY355703), a potent antimitotic antitumor agent

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174474

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

27 November 2018

1 reference

12 December 2020

Interaction of cryptophycin 1 with tubulin and microtubules

1 reference

12 December 2020

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

1 reference

12 December 2020

Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line

1 reference

12 December 2020

Characterization of the beta-methylaspartate-alpha-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway

1 reference

12 December 2020

Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA204716F

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21823639%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21823639%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

21823639

2 references