Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase (Q28246466)

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J S Bignon

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K A Siminovitch

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D R Branch

Journal of Biological Chemistry

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language of work or name

English

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publication date

22 August 1997

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published in

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volume

272

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issue

34

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page(s)

21113-9

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cites work

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src

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Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

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Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

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Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src

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Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

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The when and how of Src regulation

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Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

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Autophosphorylation of purified c-Src at its primary negative regulation site.

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Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

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Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases

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Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.

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Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

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A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

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Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

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Isolation of a src homology 2-containing tyrosine phosphatase

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Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences

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Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets

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Src kinase tyrosine phosphorylates PTP1C, a protein tyrosine phosphatase containing Src homology-2 domains that down-regulates cell proliferation

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A new monoclonal antibody which selectively recognizes the active form of Src tyrosine kinase

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Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice

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Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells

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Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates

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Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains

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Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527

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Protein kinase C phosphorylates pp60src at a novel site.

21 January 2018

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Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain

21 January 2018

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Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

21 January 2018

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Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand

21 January 2018

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Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

21 January 2018

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Assembly and function of a cytosolic form of NADH-specific isocitrate dehydrogenase in yeast

21 January 2018

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Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

21 January 2018

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Sperm-Egg Binding Protein or Proto-Oncogene?

21 January 2018

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Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets

21 January 2018

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Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

21 January 2018

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Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process

21 January 2018

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Dynamics of Oxidation of a Fe2+-Bearing Aluminosilicate (Basaltic) Melt

21 January 2018

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