Neutrophil serine proteases: specific regulators of inflammation (Q28248366)

Nature Reviews Immunology

Europe PubMed Central

title

Neutrophil serine proteases: specific regulators of inflammation (English)

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Christine T N Pham

1

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language of work or name

English

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publication date

July 2006

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published in

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volume

6

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issue

7

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page(s)

541-50

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cites work

Neutrophil granules and secretory vesicles in inflammation

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Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

31 March 2020

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

31 March 2020

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Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

31 March 2020

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Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase

31 March 2020

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A critical role for neutrophil elastase in experimental bullous pemphigoid

31 March 2020

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Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

31 March 2020

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Dipeptidyl peptidase I regulates the development of collagen-induced arthritis

31 March 2020

1 reference

Chediak-Higashi Syndrome: a rare disorder of lysosomes and lysosome related organelles

31 March 2020

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Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases

31 March 2020

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Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition

31 March 2020

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Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

31 March 2020

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Characterization of the mouse neutrophil elastase gene and localization to chromosome 10

31 March 2020

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Antibiotic proteins of human polymorphonuclear leukocytes

31 March 2020

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Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils

31 March 2020

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The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression

31 March 2020

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Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis

31 March 2020

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Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis

31 March 2020

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

31 March 2020

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Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice

31 March 2020

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An unusual specificity in the activation of neutrophil serine proteinase zymogens

31 March 2020

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Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G.

31 March 2020

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Carboxyl-terminal prodomain-deleted human leukocyte elastase and cathepsin G are efficiently targeted to granules and enzymatically activated in the rat basophilic/mast cell line RBL.

31 March 2020

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Hereditary neutropenia: dogs explain human neutrophil elastase mutations

31 March 2020

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Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.

31 March 2020

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Localization of serglycin in human neutrophil granulocytes and their precursors

31 March 2020

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Plasma membrane targeting of exocytic SNARE proteins.

31 March 2020

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Intracellular location of SNAP-25 in human neutrophils.

31 March 2020

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Human neutrophil and mast cell proteases implicated in inflammation

31 March 2020

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SLPI and elafin: one glove, many fingers.

31 March 2020

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Structure of a serpin-protease complex shows inhibition by deformation

31 March 2020

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The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.

31 March 2020

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Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects

31 March 2020

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Chemotactic activity of elastin-derived peptides

31 March 2020

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Neutrophil elastase targets virulence factors of enterobacteria

31 March 2020

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Tailoring an antibacterial peptide of human lysosomal cathepsin G to enhance its broad-spectrum action against antibiotic-resistant bacterial pathogens

31 March 2020

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Antimicrobial peptides of multicellular organisms

31 March 2020

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Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase

31 March 2020

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Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense

31 March 2020

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Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

31 March 2020

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Neutrophil extracellular traps kill bacteria

31 March 2020

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Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

31 March 2020

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Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity

31 March 2020

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Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion

31 March 2020

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Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils

31 March 2020

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The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.

31 March 2020

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Membrane receptors are not required to deliver granzyme B during killer cell attack

31 March 2020

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Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters

31 March 2020

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Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis

31 March 2020

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Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3.

31 March 2020

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Amino-terminal processing of chemokine ENA-78 regulates biological activity

31 March 2020

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Proteolytic activation of alternative CCR1 ligands in inflammation

31 March 2020

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Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity

31 March 2020

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Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration

31 March 2020

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Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases

31 March 2020

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

31 March 2020

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

31 March 2020

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In vitro processing of human tumor necrosis factor-alpha.

31 March 2020

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Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

31 March 2020

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Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin

31 March 2020

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Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation

31 March 2020

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Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo

31 March 2020

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Integrin signaling to the actin cytoskeleton.

31 March 2020

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Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering

31 March 2020

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Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation

31 March 2020

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PARticipation in inflammation

31 March 2020

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Cathepsin G activates protease-activated receptor-4 in human platelets

31 March 2020

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Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

31 March 2020

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Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2.

31 March 2020

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Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2.

31 March 2020

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Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium

31 March 2020

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Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

31 March 2020

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Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.

31 March 2020

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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

31 March 2020

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Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor

31 March 2020

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Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species

31 March 2020

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Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells

31 March 2020

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Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme

31 March 2020

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Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.

31 March 2020

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Neutrophil-mediated epithelial injury during transmigration: role of elastase

31 March 2020

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Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice

31 March 2020

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Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

31 March 2020

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Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants

31 March 2020

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Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways

31 March 2020

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Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase

31 March 2020

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Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

31 March 2020

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Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

31 March 2020

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Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis

31 March 2020

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Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice

31 March 2020

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Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1841

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Consolidated OpenCitations Corpus – April 2017

386962

386962

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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