Microtubules as a target for anticancer drugs (Q28253993)

Direct Analysis of Tubulin Expression in Cancer Cell Lines by Electrospray Ionization Mass Spectrometry

Europe PubMed Central

title

Microtubules as a target for anticancer drugs (English)

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Mary Ann Jordan

1

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Leslie Wilson

series ordinal

2

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language of work or name

English

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publication date

April 2004

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published in

Nature Reviews Cancer

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volume

4

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page(s)

253-65

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issue

4

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cites work

1 reference

The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization

31 March 2020

1 reference

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

31 March 2020

1 reference

The oncoprotein 18/stathmin family of microtubule destabilizers

31 March 2020

1 reference

The interaction of TOGp with microtubules and tubulin

31 March 2020

1 reference

Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin

31 March 2020

1 reference

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

31 March 2020

1 reference

Tubulin/microtubules: still a promising target for new chemotherapeutic agents

31 March 2020

1 reference

Microtubule dynamics: treadmilling comes around again

31 March 2020

1 reference

Dynamic instability of microtubule growth

31 March 2020

1 reference

Opposite end assembly and disassembly of microtubules at steady state in vitro

31 March 2020

1 reference

Microtubule treadmilling: what goes around comes around

31 March 2020

1 reference

Microtubule treadmilling in vivo

31 March 2020

1 reference

Sustained Microtubule Treadmilling in Arabidopsis Cortical Arrays

31 March 2020

1 reference

Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau

31 March 2020

1 reference

Kinetochore fibre dynamics outside the context of the spindle during anaphase

31 March 2020

1 reference

Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators

31 March 2020

1 reference

Structural insight into microtubule function

31 March 2020

1 reference

Microtubule dynamics: taking aim at a moving target

31 March 2020

1 reference

Determination of the size and chemical nature of the stabilizing "cap" at microtubule ends using modulators of polymerization dynamics

31 March 2020

1 reference

Concerning the chemical nature of tubulin subunits that cap and stabilize microtubules

31 March 2020

1 reference

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

31 March 2020

1 reference

Microtubule dynamics: new surprises from an old MAP.

31 March 2020

1 reference

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin.

31 March 2020

1 reference

Surfing on microtubule ends

31 March 2020

1 reference

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

31 March 2020

1 reference

Cytoplasmic linker proteins promote microtubule rescue in vivo

31 March 2020

1 reference

Microtubule dynamics and kinetochore function in mitosis

31 March 2020

1 reference

Tubulin dynamics in cultured mammalian cells

31 March 2020

1 reference

Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin

31 March 2020

1 reference

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts

31 March 2020

1 reference

Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis

31 March 2020

1 reference

Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells

31 March 2020

1 reference

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

31 March 2020

1 reference

Dynamic elastic behavior of alpha-satellite DNA domains visualized in situ in living human cells

31 March 2020

1 reference

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence

31 March 2020

1 reference

Mitotic forces control a cell-cycle checkpoint

31 March 2020

1 reference

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint

31 March 2020

1 reference

Cell cycle checkpoints: arresting progress in mitosis

31 March 2020

1 reference

Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation

31 March 2020

1 reference

Antimitotic peptides and depsipeptides

31 March 2020

1 reference

Biochemistry of benzimidazole resistance

31 March 2020

1 reference

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

31 March 2020

1 reference

The solid state, solution and tubulin-bound conformations of agents that promote microtubule stabilization

31 March 2020

1 reference

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

31 March 2020

1 reference

Taxol suppresses dynamics of individual microtubules in living human tumor cells

31 March 2020

1 reference

Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: a push-pull mechanism

31 March 2020

1 reference

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work

31 March 2020

1 reference

31 March 2020

Vincristine revisited

1 reference

Chemotherapy-induced peripheral neuropathy

31 March 2020

1 reference

Taxol neuropathy. Electrodiagnostic and sural nerve biopsy findings

31 March 2020

1 reference

Interaction of vinblastine with steady-state microtubules in vitro.

31 March 2020

1 reference

Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

31 March 2020

1 reference

Stoichiometry of the vinblastine-induced self-association of calf brain tubulin.

31 March 2020

1 reference

Identification of a distinct class of vinblastine binding sites on microtubules.

31 March 2020

1 reference

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

31 March 2020

1 reference

Promotion of microtubule assembly in vitro by taxol

31 March 2020

1 reference

How to make taxol from scratch

31 March 2020

1 reference

Managing taxane toxicities

31 March 2020

1 reference

Structure of tubulin at 6.5 A and location of the taxol-binding site.

31 March 2020

1 reference

Substoichiometric binding of taxol suppresses microtubule dynamics.

31 March 2020

1 reference

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

31 March 2020

1 reference

Interactions of colchicine with tubulin

31 March 2020

1 reference

Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes

31 March 2020

1 reference

The biology of the combretastatins as tumour vascular targeting agents

31 March 2020

1 reference

The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

31 March 2020

1 reference

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

31 March 2020

1 reference

P-glycoprotein: from genomics to mechanism.

31 March 2020

1 reference

Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators

31 March 2020

1 reference

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

31 March 2020

1 reference

Overcoming multidrug resistance in taxane chemotherapy

31 March 2020

1 reference

Mechanisms of Taxol resistance related to microtubules.

31 March 2020

1 reference

Purification and characterization of tubulin from parental and vincristine-resistant HOB1 lymphoma cells

31 March 2020

1 reference

Characterization of a taxol-resistant human small-cell lung cancer cell line

31 March 2020

1 reference

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

31 March 2020

1 reference

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

31 March 2020

1 reference

Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance

31 March 2020

1 reference

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

31 March 2020

1 reference

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

31 March 2020

1 reference

Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.

31 March 2020

1 reference

Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol

31 March 2020

1 reference

Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: a possible mechanistic basis for its antitumor action

31 March 2020

1 reference

Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone-refractory prostate cancer

31 March 2020

1 reference

Vinorelbine tartrate and paclitaxel combinations: enhanced activity against in vivo P388 murine leukemia cells

31 March 2020

1 reference

In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines

31 March 2020

1 reference

Docetaxel in combination with doxorubicin or vinorelbine

31 March 2020

1 reference

Simultaneous combination of microtubule depolymerizing and stabilizing agents acts at low doses.

31 March 2020

1 reference

Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule

31 March 2020

1 reference

Novel aspects of natural and modified vinca alkaloids

31 March 2020

1 reference

Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia

31 March 2020

1 reference

Chemotherapy for small cell lung cancer

31 March 2020

1 reference

Oral vinorelbine in combination with cisplatin: a novel active regimen in advanced non-small-cell lung cancer.

31 March 2020

1 reference

Monotherapy options in the management of metastatic breast cancer

31 March 2020

1 reference

Interaction of the antitumor compound cryptophycin-52 with tubulin

31 March 2020

1 reference

Interaction of cryptophycin 1 with tubulin and microtubules

31 March 2020

1 reference

Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.

31 March 2020

1 reference

Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

31 March 2020

1 reference

Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1

31 March 2020

1 reference

Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin

31 March 2020

1 reference

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

31 March 2020

1 reference

2-Methoxyestradiol, a promising anticancer agent

31 March 2020

1 reference

Taxol binds to cellular microtubules

31 March 2020

1 reference

Taxol binds to polymerized tubulin in vitro

31 March 2020

1 reference

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition.

31 March 2020

1 reference

First-line chemotherapy for NSCLC: an overview of relevant trials.

31 March 2020

1 reference

Second line chemotherapy for NSCLC: establishing a gold standard

31 March 2020

1 reference

The biology and medicinal chemistry of epothilones

31 March 2020

1 reference

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

31 March 2020

1 reference

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

31 March 2020

1 reference

Anticancer therapy with novel tubulin-interacting drugs

31 March 2020

1 reference

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

31 March 2020

1 reference

Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration

31 March 2020

1 reference

Overview of rational and individualized therapeutic strategies for non-Hodgkin's lymphomas

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1317

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

593914

1020709483

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593914

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference