Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists (Q28254889)

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Yahong Wang

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Ling-Yang Hao

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Xikui Liu

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Chuck A Lesch

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Brian M Sanchez

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Jay M Wendling

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Rodney W Morgan

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Tom D Aicher

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Laura L Carter

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Peter L Toogood

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Gary D Glick

Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets

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language of work or name

English

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publication date

February 2015

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published in

Nature Chemical Biology

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volume

11

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issue

2

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page(s)

141-7

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cites work

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

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Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

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Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

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Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

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Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

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Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

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Metabolic checkpoints in activated T cells

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A complex issue on CD4(+) T-cell subsets

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T(H)17 cells in tumour immunity and immunotherapy.

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Dynamic regulatory network controlling TH17 cell differentiation

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A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)

21 January 2018

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Sterols and oxysterols in immune cell function

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LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

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ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation

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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

21 January 2018

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Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

21 January 2018

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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

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Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

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Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells

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Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo

21 January 2018

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Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein

21 January 2018

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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

21 January 2018

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Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells

21 January 2018

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Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

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Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

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Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

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25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

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24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation

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Control of TH17 cells occurs in the small intestine.

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

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Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

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Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients

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Cellular cholesterol trafficking and compartmentalization

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Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo

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Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE).

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Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women

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Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

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mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

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Innate IL-17-producing cells: the sentinels of the immune system

21 January 2018

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Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation

21 January 2018

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Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα.

21 January 2018

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Therapeutic potential of targeting IL-17

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25558972

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxysterols and atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25558972

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1714

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25558972

1 reference

Consolidated OpenCitations Corpus – April 2017