Phosphodiesterases in the CNS: targets for drug development (Q28255355)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16883304%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

review article

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title

Phosphodiesterases in the CNS: targets for drug development (English)

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28 December 2019

1

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28 December 2019

author name string

W Stephen Faraci

series ordinal

2

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28 December 2019

Christopher J Schmidt

series ordinal

3

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28 December 2019

language of work or name

English

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publication date

1 August 2006

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Nature Reviews Drug Discovery

28 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16883304%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

5

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28 December 2019

issue

8

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28 December 2019

page(s)

660-670

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In silico prediction models for blood-brain barrier permeation

28 December 2019

cites work

1 reference

Studies on the mechanism of hormone action

21 January 2018

1 reference

Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP.

31 March 2020

1 reference

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

31 March 2020

1 reference

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

31 March 2020

1 reference

Cyclic nucleotide-gated ion channels: an extended family with diverse functions

31 March 2020

1 reference

The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases

31 March 2020

1 reference

A family of cAMP-binding proteins that directly activate Rap1

31 March 2020

1 reference

Epac: a new cAMP target and new avenues in cAMP research

31 March 2020

1 reference

AKAPs: from structure to function

31 March 2020

1 reference

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

31 March 2020

1 reference

Tailoring cAMP-signalling responses through isoform multiplicity

31 March 2020

1 reference

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

31 March 2020

1 reference

Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft)

31 March 2020

1 reference

Keynote review: phosphodiesterase-4 as a therapeutic target

31 March 2020

1 reference

dunce, a mutant of Drosophila deficient in learning

31 March 2020

1 reference

Phosphodiesterase inhibitors for cognitive enhancement

31 March 2020

1 reference

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

31 March 2020

1 reference

Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear

31 March 2020

1 reference

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

31 March 2020

1 reference

Results of a phase II study of the antidepressant effect of rolipram

31 March 2020

1 reference

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein.

31 March 2020

1 reference

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

31 March 2020

1 reference

Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications.

31 March 2020

1 reference

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

31 March 2020

1 reference

Rolipram, a phosphodiesterase-4-selective inhibitor, promotes the survival of cultured rat dopaminergic neurons.

31 March 2020

1 reference

Rolipram enhances the development of voltage-dependent Ca2+ current and serotonin-induced current in rat pheochromocytoma cells

31 March 2020

1 reference

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

31 March 2020

1 reference

Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase.

31 March 2020

1 reference

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

31 March 2020

1 reference

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

31 March 2020

1 reference

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

31 March 2020

1 reference

Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species.

31 March 2020

1 reference

Expression of the specific type IV phosphodiesterase gene PDE4B3 during different phases of long-term potentiation in single hippocampal slices of rats in vitro.

31 March 2020

1 reference

Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs

31 March 2020

1 reference

Neuronal expression of cAMP-specific phosphodiesterase 7B mRNA in the rat brain

31 March 2020

1 reference

Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons

31 March 2020

1 reference

Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization

31 March 2020

1 reference

Identification of human PDE7B, a cAMP-specific phosphodiesterase

31 March 2020

1 reference

Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase

31 March 2020

1 reference

Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.

31 March 2020

1 reference

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

31 March 2020

1 reference

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies

31 March 2020

1 reference

Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain

31 March 2020

1 reference

Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat.

31 March 2020

1 reference

Phosphodiesterase type 5 inhibition improves early memory consolidation of object information

31 March 2020

1 reference

Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats

31 March 2020

1 reference

Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development

31 March 2020

1 reference

Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues

31 March 2020

1 reference

The role of the cerebellum in cognition and behavior: a selective review

31 March 2020

1 reference

Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression

31 March 2020

1 reference

Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain

31 March 2020

1 reference

Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials

31 March 2020

1 reference

Expression of cGMP-specific phosphodiesterase 9A mRNA in the rat brain.

31 March 2020

1 reference

Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence

31 March 2020

1 reference

A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3.

31 March 2020

1 reference

31 March 2020

Chromosome 21 workshop.

1 reference

A cyclic GMP-stimulated cyclic nucleotide phosphodiesterase gene is highly expressed in the limbic system of the rat brain

31 March 2020

1 reference

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

31 March 2020

1 reference

A cGMP-signaling pathway in a subset of olfactory sensory neurons

31 March 2020

1 reference

Platelet cyclic adenosine monophosphate phosphodiesterases: targets for regulating platelet-related thrombosis

31 March 2020

1 reference

Role of phosphodiesterase and protein kinase G on nitric oxide-induced inhibition of prolactin release from the rat anterior pituitary

31 March 2020

1 reference

Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus

31 March 2020

1 reference

Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance

31 March 2020

1 reference

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

31 March 2020

1 reference

Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase

31 March 2020

1 reference

Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A

31 March 2020

1 reference

Immunohistochemical localization of PDE10A in the rat brain

31 March 2020

1 reference

31 March 2020

1 reference

Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function.

31 March 2020

1 reference

Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.

31 March 2020

1 reference

Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants.

31 March 2020

1 reference

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

31 March 2020

1 reference

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

31 March 2020

1 reference

Importance of P-glycoprotein at blood-tissue barriers

31 March 2020

1 reference

Computational approaches to the prediction of the blood-brain distribution

31 March 2020

1 reference

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

31 March 2020

1 reference

Structural basis for the activity of drugs that inhibit phosphodiesterases

31 March 2020

1 reference

A general pattern for substrate recognition by P-glycoprotein.

31 March 2020

1 reference

Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

31 March 2020

1 reference

Phosphodiesterase 5 inhibitors: current status and potential applications

31 March 2020

1 reference

Efficacy and tolerability of tadalafil, a novel phosphodiesterase 5 inhibitor, in treatment of erectile dysfunction

31 March 2020

1 reference

31 March 2020

1 reference

Update on the therapeutic potential of PDE4 inhibitors

31 March 2020

1 reference

Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

31 March 2020

1 reference

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

31 March 2020

1 reference

A new chemical tool for exploring the physiological function of the PDE2 isozyme

31 March 2020

1 reference

Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum

31 March 2020

1 reference

Differential cellular pattern of gene expression for two distinct cGMP-inhibited cyclic nucleotide phosphodiesterases in developing and mature rat brain

31 March 2020

1 reference

Tissue expression, distribution, and regulation of PDE5.

31 March 2020

1 reference

Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2058

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16883304%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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