Glycolysis inhibition for anticancer treatment (Q28256222)

Europe PubMed Central

title

Glycolysis inhibition for anticancer treatment (English)

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author name string

H Pelicano

1

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D S Martin

2

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R-H Xu

3

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P Huang

The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency

4

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language of work or name

English

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publication date

7 August 2006

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published in

Oncogene

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volume

25

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page(s)

4633-46

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issue

34

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cites work

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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Identification of genes differentially induced by hypoxia in pancreatic cancer cells

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S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

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Germline SDHD mutation in familial phaeochromocytoma

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7 January 2021

The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer

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Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).

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Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis.

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Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases

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7 January 2021

Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growth

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7 January 2021

The hypoxia-inducible factor and tumor progression along the angiogenic pathway.

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7 January 2021

Glufosfamide administered using a 1-hour infusion given as first-line treatment for advanced pancreatic cancer. A phase II trial of the EORTC-new drug development group

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7 January 2021

Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death

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7 January 2021

Evolution and regulatory role of the hexokinases

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7 January 2021

Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications.

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7 January 2021

Nuclear localization of a lactic dehydrogenase with single-stranded DNA-binding properties.

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7 January 2021

Mitochondrial mutagenesis and oxidative stress in human prostate cancer

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7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

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7 January 2021

The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study

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7 January 2021

Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study

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7 January 2021

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

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7 January 2021

Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

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7 January 2021

The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R ty

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7 January 2021

ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).

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7 January 2021

Serum phosphohexose isomerase activities in patients with colorectal cancer.

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7 January 2021

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

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7 January 2021

Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant ehrlich ascites tumor cells through modulation of energy metabolism

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7 January 2021

Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?

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7 January 2021

Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility

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7 January 2021

Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells

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7 January 2021

Chemosensitization and radiosensitization of tumors by plant polyphenols

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7 January 2021

Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma

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7 January 2021

Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group

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7 January 2021

Hexokinase binding to mitochondria: a basis for proliferative energy metabolism

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7 January 2021

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

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7 January 2021

Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex

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7 January 2021

The detection of hexokinase, glucosephosphate isomerase and phosphoglucomutase activities in polyacrylamide gels after electrophoresis: a novel method using immobilized glucose 6-phosphate dehydrogenase

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7 January 2021

Transcriptional regulation of the Saccharomyces cerevisiae HXK1, HXK2 and GLK1 genes.

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7 January 2021

Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer

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7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neurons

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7 January 2021

"Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis.

1 reference

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7 January 2021

alpha-Chlorohydrin inhibits glyceraldehyde-3-phosphate dehydrogenase in multiple organs as well as in sperm

1 reference

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7 January 2021

Metabolism of 36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity

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7 January 2021

2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic

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7 January 2021

Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo.

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7 January 2021

Neurotoxic effects of 6-aminonicotinamide on cultures of central nervous tissue.

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7 January 2021

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

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7 January 2021

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

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7 January 2021

Proteome analysis of human lung squamous carcinoma

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7 January 2021

Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Tumor cell autocrine motility factor

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7 January 2021

The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications

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7 January 2021

Hypersensitization of tumor cells to glycolytic inhibitors

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7 January 2021

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

1 reference

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7 January 2021

Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy

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7 January 2021

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

1 reference

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7 January 2021

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

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7 January 2021

Functional properties of neuronal and glial isoenzymes of brain enolase

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7 January 2021

A concomitant ATP-depleting strategy markedly enhances anticancer agent activity

1 reference

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7 January 2021

Marked enhancement in vivo of paclitaxel's (taxol's) tumor-regressing activity by ATP-depleting modulation

1 reference

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7 January 2021

Biochemical modulation of tumor cell energy in vivo: II. A lower dose of adriamycin is required and a greater antitumor activity is induced when cellular energy is depressed.

1 reference

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7 January 2021

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

1 reference

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7 January 2021

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase

1 reference

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7 January 2021

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Identification of the NAD(+)-binding fold of glyceraldehyde-3-phosphate dehydrogenase as a novel RNA-binding domain.

1 reference

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7 January 2021

Inhibition of aerobic glycolysis in normal and neoplastic lymphoid cells induced by Lonidamine [1-(2,4-dichlorobenzyl)-I-H-indazol-3-carboxylic acid]

1 reference

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7 January 2021

Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast.

1 reference

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7 January 2021

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

1 reference

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7 January 2021

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

1 reference

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7 January 2021

Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide

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7 January 2021

Hexokinase II: the integration of energy metabolism and control of apoptosis

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7 January 2021

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

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7 January 2021

Mutations of the SDHB and SDHD genes

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

ROS stress in cancer cells and therapeutic implications

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Study of the interaction of glyceraldehyde-3-phosphate dehydrogenase with DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle

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7 January 2021

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

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7 January 2021

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Activation of phosphatidylinositol 3-kinase by insulin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent

1 reference

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7 January 2021

Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications

1 reference

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7 January 2021

Nuclear translocation of GAPDH-GFP fusion protein during apoptosis

1 reference

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7 January 2021

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

1 reference

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7 January 2021

Mitochondrial dysfunction is a common phenotype in aging and cancer

1 reference

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7 January 2021

New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells

1 reference

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7 January 2021

Improving male mating competitiveness and survival in the field for medfly, Ceratitis capitata (Diptera: Tephritidae) SIT programs

1 reference

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7 January 2021

Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs

1 reference

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7 January 2021

Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Purification and properties of phosphofructokinase 2/fructose 2,6-bisphosphatase from chicken liver and from pigeon muscle

1 reference

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7 January 2021

Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

On the Origin of Cancer Cells

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7 January 2021

Caloric restriction mimetics: metabolic interventions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5.

1 reference

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

1 reference

7 January 2021

Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209597

7 January 2021

Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.

1 reference

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7 January 2021

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

1 reference

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7 January 2021

Mutation in D-loop region of mitochondrial DNA in gastric cancer and its significance

1 reference

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7 January 2021

Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice

1 reference

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7 January 2021

Alkylating DNA damage stimulates a regulated form of necrotic cell death

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7 January 2021

Cancer metabolism: facts, fantasy, and fiction

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209597

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1653144

1036840626

0 references

1653144

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference