Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy (Q28259250)

1

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Suni Lee

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Takashi Katsu

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Takemi Otsuki

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Tsuyoshi Inoue

Early identification of refractory epilepsy

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language of work or name

English

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publication date

20 March 2015

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published in

Science

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volume

347

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page(s)

1362-7

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issue

6228

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Molecular targets for antiepileptic drug development

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

The green fluorescent protein

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAA1299

Recovery of learning and memory is associated with chromatin remodelling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Metabolic control of vesicular glutamate transport and release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

The ketogenic diet: metabolic influences on brain excitability and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Neuronal metabolism governs cortical network response state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Astroglial metabolic networks sustain hippocampal synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Astrocyte-neuron lactate transport is required for long-term memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Regulation of blood glucose by hypothalamic pyruvate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

The ketogenic diet changes metabolite levels in hippocampal extracellular fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Ketogenic diet in patients with Dravet syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Feedforward inhibitory connections from multiple thalamic cells to multiple regular-spiking cells in layer 4 of the somatosensory cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Preservation of the direct and indirect pathways in an in vitro preparation of the mouse basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Intrinsic firing patterns of diverse neocortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Electrophysiological and immunocytochemical characterization of GABA and dopamine neurons in the substantia nigra of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Action potentials recorded with patch-clamp amplifiers: are they genuine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Synaptic activation of glutamate transporters in hippocampal astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Modulation of ATP-sensitive K+ channels in skeletal muscle by intracellular protons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Direct activation of the ATP-sensitive potassium channel by oxygen free radicals in guinea-pig ventricular cells: its potentiation by MgADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

In vivo and in vitro effects of pilocarpine: relevance to ictogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Glucose and lactate supply to the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299

Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial ParasitePlasmodiumfalciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA1299