A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene (Q28259719)

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L Soceneantu

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A Sardini

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W N Konings

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C F Higgins

Prevention of drug access to bacterial targets: permeability barriers and active efflux

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language of work or name

English

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publication date

15 January 1998

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published in

Nature

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volume

391

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issue

6664

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page(s)

291-5

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cites work

1 reference

7 January 2021

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

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7 January 2021

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

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7 January 2021

ABC Transporters: From Microorganisms to Man

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7 January 2021

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

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7 January 2021

Genetic analysis of the multidrug transporter

1 reference

7 January 2021

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1 reference

7 January 2021

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

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7 January 2021

Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

1 reference

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

7 January 2021

The establishment of two cell lines from the insectspodoptera frugiperda (lepidoptera; noctuidae)

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7 January 2021

P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

1 reference

7 January 2021

Dexniguldipine-HCl is a potent allosteric inhibitor of [3H]vinblastine binding to P-glycoprotein of CCRF ADR 5000 cells

1 reference

7 January 2021

Mutually co-operative interactions between modulators of P-glycoprotein

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7 January 2021

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

1 reference

7 January 2021

Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

1 reference

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

7 January 2021

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

7 January 2021

Functional interactions between synthetic alkyl phospholipids and the ABC transporters P-glycoprotein, Ste-6, MRP, and Pgh 1

1 reference

7 January 2021

Is the multidrug transporter a flippase?

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7 January 2021

Action of calcium antagonists on multidrug resistant cells. Specific cytotoxicity independent of increased cancer drug accumulation.

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7 January 2021

Reconstitution of drug transport by purified P-glycoprotein

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7 January 2021

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

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7 January 2021