Myosin phosphatase: structure, regulation and function (Q28260078)

Molecular and Cellular Biochemistry

Europe PubMed Central

title

Myosin phosphatase: structure, regulation and function (English)

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4

David J Hartshorne

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author name string

Masaaki Ito

series ordinal

1

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Takeshi Nakano

series ordinal

2

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Ferenc Erdodi

series ordinal

3

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language of work or name

English

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publication date

April 2004

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published in

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volume

259

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page(s)

197-209

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issue

1-2

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cites work

Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21

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12 December 2020

Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity

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12 December 2020

cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha

1 reference

12 December 2020

Recombinant small subunit of smooth muscle myosin light chain phosphatase. Molecular properties and interactions with the targeting subunit

1 reference

12 December 2020

Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton

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12 December 2020

Myosin light chain phosphatase: subunit composition, interactions and regulation

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12 December 2020

Dephosphorylation of distinct sites on the 20 kDa myosin light chain by smooth muscle myosin phosphatase

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12 December 2020

Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation

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12 December 2020

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

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12 December 2020

Rho-associated kinase of chicken gizzard smooth muscle

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12 December 2020

Defining the Structural Determinants and a Potential Mechanism for Inhibition of Myosin Phosphatase by the Protein Kinase C-potentiated Inhibitor Protein of 17 kDa

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12 December 2020

Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle

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12 December 2020

Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle

1 reference

12 December 2020

Agonist-induced changes in the phosphorylation of the myosin- binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle

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12 December 2020

Signal transduction and regulation in smooth muscle

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12 December 2020

Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms

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12 December 2020

Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.

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12 December 2020

Interactions and properties of smooth muscle myosin phosphatase.

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12 December 2020

A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping

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12 December 2020

cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

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12 December 2020

M20, the small subunit of PP1M, binds to microtubules

1 reference

12 December 2020

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

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12 December 2020

Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase

1 reference

12 December 2020

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

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12 December 2020

Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

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12 December 2020

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium

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12 December 2020

Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation

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12 December 2020

Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase

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12 December 2020

Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton

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12 December 2020

The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product

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12 December 2020

Identification of MYPT1 and NIPP1 as subunits of protein phosphatase 1 in rat liver cytosol

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12 December 2020

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.

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12 December 2020

Interactions of the subunits of smooth muscle myosin phosphatase.

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12 December 2020

Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation

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12 December 2020

Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.

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12 December 2020

Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle

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12 December 2020

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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12 December 2020

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

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12 December 2020

Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor

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12 December 2020

A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch.

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12 December 2020

Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase

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12 December 2020

TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells

1 reference

12 December 2020

Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

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12 December 2020

Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle

1 reference

12 December 2020

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

1 reference

12 December 2020

Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase

1 reference

12 December 2020

Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity

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12 December 2020

Phosphorylation of MYPT1 by protein kinase C attenuates interaction with PP1 catalytic subunit and the 20 kDa light chain of myosin

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12 December 2020

Interaction of myosin phosphatase target subunit 1 with the catalytic subunit of type 1 protein phosphatase

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12 December 2020

Myosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells

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12 December 2020

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

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12 December 2020

Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.

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12 December 2020

Interaction of smooth muscle myosin phosphatase with phospholipids

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12 December 2020

A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization

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12 December 2020

Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle

1 reference

12 December 2020

Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells

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12 December 2020

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

1 reference

12 December 2020

Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion

1 reference

12 December 2020

Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae

1 reference

12 December 2020

Novel in vitro and in vivo phosphorylation sites on protein phosphatase 1 inhibitor CPI-17.

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12 December 2020

Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit

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12 December 2020

Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase

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12 December 2020

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension

1 reference

12 December 2020

Cyclic GMP causes Ca2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase.

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12 December 2020

Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm

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12 December 2020

Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase

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12 December 2020

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

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12 December 2020

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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12 December 2020

Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17.

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12 December 2020

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

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12 December 2020

Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase

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12 December 2020

Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase

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12 December 2020

Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

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12 December 2020

Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits

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12 December 2020

Study of the subunit interactions in myosin phosphatase by surface plasmon resonance

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12 December 2020

Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle

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12 December 2020

Isoforms of the small non-catalytic subunit of smooth muscle myosin light chain phosphatase.

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12 December 2020

The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle

1 reference

12 December 2020

Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase

1 reference

12 December 2020

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

1 reference

12 December 2020

Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation

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12 December 2020

Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity

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12 December 2020

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

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12 December 2020

Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta

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12 December 2020

Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene

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12 December 2020

Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate

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12 December 2020

Drosophila myosin phosphatase and its role in dorsal closure.

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12 December 2020

Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats

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12 December 2020

Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells

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12 December 2020

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha

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12 December 2020

Roles of myosin phosphatase during Drosophila development.

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12 December 2020

Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase

1 reference

12 December 2020

Identification in turkey gizzard of an acidic protein related to the C-terminal portion of smooth muscle myosin light chain kinase

1 reference

12 December 2020

Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

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12 December 2020

A regulatory subunit of smooth muscle myosin bound phosphatase

1 reference

12 December 2020

Agonist-induced force enhancement: the role of isoforms and phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase

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12 December 2020

Rho as a mediator of G protein-coupled receptor signaling.

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12 December 2020

Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1

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12 December 2020

Effects of the phosphorylation of myosin phosphatase by cyclic GMP-dependent protein kinase

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12 December 2020

Identification of the endogenous smooth muscle myosin phosphatase-associated kinase

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12 December 2020

ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells

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12 December 2020

Thiophosphorylation of the 130-kDa subunit is associated with a decreased activity of myosin light chain phosphatase in alpha-toxin-permeabilized smooth muscle

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12 December 2020

Serine phosphorylation negatively regulates RhoA in vivo.

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12 December 2020

The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway.

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12 December 2020

Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition

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12 December 2020

Activation of myosin phosphatase targeting subunit by mitosis-specific phosphorylation

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12 December 2020

Selected contribution: insulin utilizes NO/cGMP pathway to activate myosin phosphatase via Rho inhibition in vascular smooth muscle

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12 December 2020

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

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12 December 2020

Differential association and localization of myosin phosphatase subunits during agonist-induced signal transduction in smooth muscle

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12 December 2020