LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor (Q28260305)

13

0 references

Paul E. Brennan

object named as

Paul E Brennan

14

0 references

Cynthia Tallant

3

object named as

Cynthia Tallant

0 references

author name string

Peter G K Clark

1

0 references

Lucas C C Vieira

2

0 references

Oleg Fedorov

4

0 references

Dean C Singleton

5

0 references

Catherine M Rogers

6

0 references

Octovia P Monteiro

7

0 references

James M Bennett

8

0 references

Roberta Baronio

9

0 references

Danette L Daniels

11

0 references

Jacqui Méndez

12

0 references

Darren J Dixon

Angewandte Chemie International Edition

15

0 references

language of work or name

English

0 references

publication date

18 May 2015

0 references

published in

0 references

volume

54

0 references

issue

21

0 references

page(s)

6217-21

0 references

cites work

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

BRD7 is a candidate tumour suppressor gene required for p53 function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Is there a link between selectivity and binding thermodynamics profiles?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

A new family of cinchona-derived bifunctional asymmetric phase-transfer catalysts: application to the enantio- and diastereoselective nitro-Mannich reaction of amidosulfones.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Thermodynamics guided lead discovery and optimization.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

The art of total synthesis through cascade reactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4449114

Prognostic relevance of BRD7 expression in colorectal carcinoma.

2 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

Pd-catalyzed intermolecular amidation of aryl halides: the discovery that xantphos can be trans-chelating in a palladium complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201501394

21 January 2018

Identifiers

DOI

10.1002/ANIE.201501394

1 reference

1 reference

1 reference

PubMed publication ID

25864491

1 reference