Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer (Q28261456)

1

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Jean-Louis Boulay

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Martin Buess

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Luigi Terracciano

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Urban Laffer

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Gabriele Mild

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Richard Herrmann

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Christoph Rochlitz

DCC: linking tumor suppressor genes and altered cell surface interactions in cancer?

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language of work or name

English

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publication date

2005

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published in

Oncology

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volume

68

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issue

2-3

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page(s)

246-55

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cites work

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In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation

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SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Evidence for a role of the JNK cascade in Smad7-mediated apoptosis

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Molecular predictors of survival after adjuvant chemotherapy for colon cancer

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Loss of heterozygosity at 18q21 is indicative of recurrence and therefore poor prognosis in a subset of colorectal cancers.

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Chromosome 18q allelic loss and prognosis in stage II and III colon cancer

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Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins

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Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

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Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

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DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

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Negative regulation of cytokine signaling pathways

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SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

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Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay.

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Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

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H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer

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H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo

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Prediction of the response of colorectal cancer to systemic therapy

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Mechanisms underlying losses of heterozygosity in human colorectal cancers

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Altered expression of E-cadherin in breast cancer

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