Structure and function of the spleen (Q28264813)

Nature Reviews Immunology

Europe PubMed Central

title

Structure and function of the spleen (English)

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author name string

Reina E Mebius

series ordinal

1

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Georg Kraal

series ordinal

2

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language of work or name

English

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publication date

August 2005

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published in

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volume

5

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issue

8

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page(s)

606-16

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cites work

The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes

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Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification

21 April 2017

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A chemokine-driven positive feedback loop organizes lymphoid follicles

21 April 2017

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

21 April 2017

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21 April 2017

Marginal-zone B cells

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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

21 April 2017

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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

21 April 2017

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Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake

21 April 2017

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Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

21 April 2017

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Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes

21 April 2017

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The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2

21 April 2017

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The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis

21 April 2017

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 April 2017

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21 April 2017

Marginal zone B cells

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Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice

21 April 2017

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

21 April 2017

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Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

21 April 2017

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Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions

21 April 2017

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NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue

21 April 2017

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

21 April 2017

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 April 2017

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Cells in the marginal zone of the spleen

21 April 2017

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Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractility

31 March 2020

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Kinetics of red blood cell passage through interendothelial slits into venous sinuses in rat spleen, analyzed by in vivo microscopy

31 March 2020

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Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review.

31 March 2020

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The human spleen during physiological stress

31 March 2020

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Iron metabolism in the reticuloendothelial system

31 March 2020

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The heme oxygenase system: a regulator of second messenger gases

31 March 2020

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Identification of the haemoglobin scavenger receptor.

31 March 2020

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Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport

31 March 2020

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Iron metabolism in pathogenic bacteria.

31 March 2020

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Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival

31 March 2020

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Extrafollicular antibody responses

31 March 2020

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A coordinated change in chemokine responsiveness guides plasma cell movements

31 March 2020

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Dendritic cells associated with plasmablast survival

31 March 2020

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Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization

31 March 2020

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Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen

31 March 2020

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Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

31 March 2020

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Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells

31 March 2020

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Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse

31 March 2020

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Splenic T zone development is B cell dependent

31 March 2020

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Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues

31 March 2020

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Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords

31 March 2020

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Chemokines in rapid leukocyte adhesion triggering and migration

31 March 2020

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The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.

31 March 2020

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SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran.

31 March 2020

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Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo

31 March 2020

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Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages

31 March 2020

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Sialic acid binding receptors (siglecs) expressed by macrophages.

31 March 2020

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B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion

31 March 2020

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B cells are crucial for both development and maintenance of the splenic marginal zone.

31 March 2020

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Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13

31 March 2020

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Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes.

31 March 2020

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Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19.

31 March 2020

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Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone

31 March 2020

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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

31 March 2020

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The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization

31 March 2020

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Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate

31 March 2020

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Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system

31 March 2020

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Integrin-mediated long-term B cell retention in the splenic marginal zone.

31 March 2020

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Pattern recognition receptors: doubling up for the innate immune response

31 March 2020

1 reference

Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1.

31 March 2020

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SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.

31 March 2020

1 reference

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus

31 March 2020

1 reference

Marginal zone macrophages and immune responses against viruses

31 March 2020

1 reference

Siglecs, sialic acids and innate immunity

31 March 2020

1 reference

Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-alpha/beta producers in mice upon intravenous challenge with herpes simplex virus

31 March 2020

1 reference

Antigen processing and presentation in vivo: the microenvironment as a crucial factor

31 March 2020

1 reference

Development and selection of marginal zone B cells

31 March 2020

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Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells.

31 March 2020

1 reference

Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis

31 March 2020

1 reference

Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infections

31 March 2020

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Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

31 March 2020

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In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

31 March 2020

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Visualization of specific B and T lymphocyte interactions in the lymph node.

31 March 2020

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Visualization of the genesis and fate of isotype-switched B cells during a primary immune response

31 March 2020

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Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex

31 March 2020

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A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp

31 March 2020

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Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues

31 March 2020

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The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment

31 March 2020

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The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

31 March 2020

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

31 March 2020

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Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity

31 March 2020

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A defect of the splanchnic mesoderm caused by the mutant gene dominant hemimelia in the mouse

31 March 2020

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Hox11 controls the genesis of the spleen

31 March 2020

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The Wilms tumor suppressor gene wt1 is required for development of the spleen.

31 March 2020

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The regulation of hemopoiesis in the spleen

31 March 2020

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Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells

31 March 2020

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Organogenesis of lymphoid tissues

31 March 2020

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

31 March 2020

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Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

31 March 2020

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Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

31 March 2020

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The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21

31 March 2020

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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

31 March 2020

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CD1high B cells: a population of mixed origin

31 March 2020

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The Three-dimensional Structure of Human Splenic White Pulp Compartments

31 March 2020

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The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?

31 March 2020

1 reference

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

31 March 2020

1 reference

Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice

31 March 2020

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Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function

31 March 2020

1 reference

Tumor Necrosis Factor and the p55TNF Receptor Are Required for Optimal Development of the Marginal Sinus and for Migration of Follicular Dendritic Cell Precursors into Splenic Follicles

31 March 2020

1 reference

Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice

31 March 2020

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The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues.

31 March 2020

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Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

31 March 2020

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Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

31 March 2020

1 reference

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

31 March 2020

1 reference

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

31 March 2020

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The splenic marginal zone is absent in alymphoplastic aly mutant mice

31 March 2020

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Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

31 March 2020

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Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase

31 March 2020

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Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway

31 March 2020

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Nuclear factor kappa B is required for the development of marginal zone B lymphocytes

31 March 2020

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Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

31 March 2020

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