Genetic variation in Toll-like receptors and disease susceptibility (Q28267031)

12 December 2020

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells

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12 December 2020

The spectrum of herpes simplex encephalitis in children

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12 December 2020

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

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12 December 2020

Functional consequences of toll-like receptor 4 polymorphisms

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12 December 2020

Oncogenically active MYD88 mutations in human lymphoma

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12 December 2020

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

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12 December 2020

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.

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12 December 2020

Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

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12 December 2020

Drosophila Toll and IL-1 receptor

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12 December 2020

The application of molecular genetic approaches to the study of human evolution

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12 December 2020

Genetic epidemiology of tuberculosis susceptibility: impact of study design

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12 December 2020

Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics

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12 December 2020

The evolutionary history of TLR4 polymorphisms in Europe

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12 December 2020

Toll-like Receptor 4 Polymorphisms and Atherogenesis

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12 December 2020

TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans

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12 December 2020

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

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12 December 2020

The immune system evolved to discriminate infectious nonself from noninfectious self

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12 December 2020

Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease

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12 December 2020

A partial form of recessive STAT1 deficiency in humans

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12 December 2020

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

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12 December 2020

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

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12 December 2020

Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection

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12 December 2020

Multiple common variants for celiac disease influencing immune gene expression

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12 December 2020

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

The importance of Toll-like receptor 2 polymorphisms in severe infections

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12 December 2020

Toll-like receptor polymorphisms and susceptibility to human disease

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12 December 2020

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

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12 December 2020

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

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12 December 2020

Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes

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12 December 2020

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

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12 December 2020

Shigella sonnei Meningitis Due to Interleukin-1 Receptor--Associated Kinase--4 Deficiency: First Association with a Primary Immune Deficiency

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12 December 2020

Genetic adaptation of the antibacterial human innate immunity network

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12 December 2020

Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility

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12 December 2020

Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury

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12 December 2020

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus

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12 December 2020

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

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12 December 2020

Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly

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12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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12 December 2020

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding

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12 December 2020

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

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12 December 2020

Balancing selection is the main force shaping the evolution of innate immunity genes

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12 December 2020

Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women

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12 December 2020

Population genetics models of common diseases

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12 December 2020

TIRAP Ser180Leu polymorphism is associated with Behcet's disease

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12 December 2020

Out of Africa: modern human origins special feature: explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from Africa

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12 December 2020

Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy.

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12 December 2020

Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.

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12 December 2020

Pyogenic bacterial infections in humans with MyD88 deficiency

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12 December 2020

Adaptation and constraint at Toll-like receptors in primates

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12 December 2020

What the Myddosome structure tells us about the initiation of innate immunity

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12 December 2020

Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation

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12 December 2020

Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody

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12 December 2020

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

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12 December 2020

IFI16 is an innate immune sensor for intracellular DNA

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12 December 2020

Integration of genetic and immunological insights into a model of celiac disease pathogenesis

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12 December 2020

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

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12 December 2020

Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections

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12 December 2020

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.

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12 December 2020

Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

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12 December 2020

Staphylococcal Pericarditis, and Liver and Paratracheal Abscesses as Presentations in Two New Cases of Interleukin-1 Receptor Associated Kinase 4 Deficiency

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12 December 2020

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution

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12 December 2020

Primary immunodeficiencies of protective immunity to primary infections

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12 December 2020

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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12 December 2020

IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease

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12 December 2020

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

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12 December 2020

Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children.

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12 December 2020

Herpes simplex virus encephalitis in human UNC-93B deficiency

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12 December 2020

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

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12 December 2020

From evolutionary genetics to human immunology: how selection shapes host defence genes

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12 December 2020

Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

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12 December 2020

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases

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12 December 2020

Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups

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12 December 2020

Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency

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12 December 2020

Autosomal recessive Interleukin-1 receptor-associated kinase 4 deficiency in fourth-degree relatives

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12 December 2020

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

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12 December 2020

A history of recurrent positive selection at the toll-like receptor 5 in primates

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12 December 2020

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

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12 December 2020

TLR3 deficiency in patients with herpes simplex encephalitis

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12 December 2020

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

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12 December 2020

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

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12 December 2020

Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study

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12 December 2020

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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12 December 2020

Pyogenic bacterial infections in humans with IRAK-4 deficiency

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12 December 2020

Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population

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12 December 2020

Regulation of adaptive immunity by the innate immune system

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12 December 2020

Rheumatoid arthritis in the developing world

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12 December 2020

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis

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12 December 2020

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome

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12 December 2020