Orthosteric and allosteric binding sites of P2X receptors (Q28267257)

European Biophysics Journal

Europe PubMed Central

title

Orthosteric and allosteric binding sites of P2X receptors (English)

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author name string

R J Evans

series ordinal

1

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language of work or name

English

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publication date

March 2009

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published in

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volume

38

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issue

3

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page(s)

319-27

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cites work

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

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Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function

21 January 2018

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Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH.

21 January 2018

1 reference

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Molecular physiology of P2X receptors

21 January 2018

1 reference

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ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

21 January 2018

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12 December 2020

The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH.

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12 December 2020

Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

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12 December 2020

Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands

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12 December 2020

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

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12 December 2020

Single channel properties of P2X2 purinoceptors

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12 December 2020

Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.

1 reference

12 December 2020

Differential modulation by copper and zinc of P2X2 and P2X4 receptor function.

1 reference

12 December 2020

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1 reference

12 December 2020

Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate

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12 December 2020

Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor.

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12 December 2020

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12 December 2020

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

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12 December 2020

Molecular properties of P2X receptors

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12 December 2020

Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface

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12 December 2020

Properties of ATP-gated channels recorded from rat sympathetic neurons: voltage dependence and regulation by Zn2+ ions.

1 reference

12 December 2020

Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors

1 reference

12 December 2020

Mutagenesis studies of conserved proline residues of human P2X receptors for ATP indicate that proline 272 contributes to channel function

1 reference

12 December 2020

NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor

1 reference

12 December 2020

Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor

1 reference

12 December 2020

Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation

1 reference

12 December 2020

Conserved negatively charged residues are not required for ATP action at P2X(1) receptors

1 reference

12 December 2020

Dual effect of acid pH on purinergic P2X3 receptors depends on the histidine 206 residue

1 reference

12 December 2020

An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

1 reference

12 December 2020

ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists

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12 December 2020

Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis

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12 December 2020

Pharmacology of cloned P2X receptors

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12 December 2020

A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site

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12 December 2020

Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions

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12 December 2020

Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition

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12 December 2020

P2X4: an ATP-activated ionotropic receptor cloned from rat brain

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12 December 2020

Effects of diadenosine polyphosphates (Ap(n)As) and adenosine polyphospho guanosines (Ap(n)Gs) on rat mesenteric artery P2X receptor ion channels

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12 December 2020

Crystal structure of an inactive duck delta II crystallin mutant with bound argininosuccinate

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12 December 2020

Molecular dissection of purinergic P2X receptor channels.

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12 December 2020

Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc

1 reference

12 December 2020

Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons

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12 December 2020

The role of positively charged amino acids in ATP recognition by human P2X(1) receptors.

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12 December 2020

Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.

1 reference

12 December 2020

Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors.

1 reference

12 December 2020

An intersubunit zinc binding site in rat P2X2 receptors

1 reference

12 December 2020

Molecular determinants of the agonist binding domain of a P2X receptor channel.

1 reference

12 December 2020

Protein consensus sequence motifs.

1 reference

12 December 2020

Zn2+ modulation of ATP-responses at recombinant P2X2 receptors and its dependence on extracellular pH.

1 reference

12 December 2020

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain.

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12 December 2020

ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics

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12 December 2020

Identification of amino acid residues contributing to the pore of a P2X receptor

1 reference

12 December 2020

Zinc and copper modulate differentially the P2X4 receptor

1 reference

12 December 2020

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

1 reference

12 December 2020

Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.

1 reference

12 December 2020

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor

1 reference

12 December 2020

Molecular properties of ATP-gated P2X receptor ion channels

1 reference

12 December 2020

Modulatory activity of extracellular H+ and Zn2+ on ATP-responses at rP2X1 and rP2X3 receptors

1 reference

12 December 2020

Zn2+ potentiates ATP-activated currents in rat sympathetic neurons.

1 reference

12 December 2020

Zn2+ potentiates excitatory action of ATP on mammalian neurons

1 reference

12 December 2020

Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper

1 reference

12 December 2020

Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor

1 reference

12 December 2020

ADP is not an agonist at P2X(1) receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets

1 reference

12 December 2020