The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development (Q28267391)

Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases

Europe PubMed Central

title

The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development (English)

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John R Cashman

1

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language of work or name

English

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publication date

1 July 2004

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published in

Drug Discovery Today

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volume

9

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issue

13

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page(s)

574-81

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Structural and catalytic properties of the mammalian flavin-containing monooxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Alternative processing events in human FMO genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Trimethylaminuria and a human FMO3 mutation database

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Flavin monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Can caffeine metabolism be used as an in-vivo probe for human flavin-containing monooxygenase activity?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Metabolism of clozapine by rat brain: the role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P-450 monooxygenases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

The molecular biology of the flavin-containing monooxygenases of man

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Two novel mutations of the FMO3 gene in a proband with trimethylaminuria

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021

Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903136-8

7 January 2021