Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway (Q28270455)

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S Y Buckman

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A P Pentland

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D J Templeton

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A R Morrison

Journal of Biological Chemistry

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language of work or name

English

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publication date

22 May 1998

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published in

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volume

273

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issue

21

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page(s)

12901-8

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cites work

Yes, but do they still get headaches?

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Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase

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cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

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Interactions of PGH synthase isozymes-1 and -2 with NSAIDs

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

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Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

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Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

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Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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Protein kinase cascades activated by stress and inflammatory cytokines

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cPLA2 is phosphorylated and activated by MAP kinase

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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

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p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta

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Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

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Mitogen-activated protein kinase cascades and regulation of gene expression

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Signalling pathways: jack of all cascades

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Regulation of transcription by MAP kinase cascades

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

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Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase

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Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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