Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials (Q28270964)

Ajulemic acid: A novel cannabinoid produces analgesia without a "high"

Europe PubMed Central

title

Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials (English)

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author name string

Summer Burstein

series ordinal

1

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language of work or name

English

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publication date

29 June 2005

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published in

The AAPS Journal

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volume

7

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issue

1

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page(s)

E143-8

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Ajulemic acid (CT3): a potent analog of the acid metabolites of THC.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

A major metabolite of delta 1-tetrahydrocannabinol reduces its cataleptic effect in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Prostaglandins and cannabis--XVI. Antagonism of delta 1-tetrahydrocannabinol action by its metabolites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Cannabinoids and pain responses: a possible role for prostaglandins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Further studies on the antinociceptive effects of delta 6-THC-7-oic acid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Activation and Binding of Peroxisome Proliferator-Activated Receptor γ by Synthetic Cannabinoid Ajulemic Acid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Dimethylheptyl-THC-11 oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751505

Metabolism of Δ1(6)-Tetrahydro-cannabinol, an Active Marihuana Constituent

27 November 2018

1 reference

12 December 2020

Hydroxylation of trans-Δ1-tetrahydrocannabinol by a hepatic microsomal monooxygenase

1 reference

12 December 2020

Isolation and characterization of two major urinary metabolites of 1 -tetrahydrocannabinol

1 reference

12 December 2020

Metabolic pathways for the transformation of delta 1-tetrahydrocannabinol in mouse hepatic microsomes

1 reference

12 December 2020

Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid

1 reference

12 December 2020

Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities

1 reference

12 December 2020

Analgesic effects of 1',1' dimethylheptyl-delta8-THC-11-oic acid (CT3) in mice

1 reference

12 December 2020