Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms (Q28272762)

Europe PubMed Central

title

Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms (English)

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author name string

M C Schaub

1

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M A Hefti

2

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R A Zuellig

3

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I Morano

Cardiac hypertrophy: useful adaptation or pathologic process?

4

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language of work or name

English

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publication date

February 1998

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published in

Cardiovascular Research

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volume

37

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issue

2

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page(s)

381-404

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cites work

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The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy

7 January 2021

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Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy

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Hydrolysis of ATP and reversible binding to F-actin by myosin heavy chains free of all light chains

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Regulation and kinetics of the actin-myosin-ATP interaction

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7 January 2021

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7 January 2021

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Human atrial and ventricular myosin light-chains subunits in the adult and during development

7 January 2021

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Skinned fibers of human atrium and ventricle: myosin isoenzymes and contractility

7 January 2021

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The function of myosin and myosin light chain kinase phosphorylation in smooth muscle

7 January 2021

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Myosin P-light chain isoenzymes in the human heart: evidence for diphosphorylation of the atrial P-LC form

7 January 2021

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Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

7 January 2021

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Local changes in myosin types in diseased human atrial myocardium: a quantitative immunofluorescence study

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Myosin isoenzyme distribution in overloaded human atrial tissue

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Left ventricular isomyosins in normal and hypertrophied rat and human hearts

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Distribution of myosin isozymes in human atrial and ventricular myocardium: comparison in normal and overloaded heart

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Distribution pattern of alpha and beta myosin in normal and diseased human ventricular myocardium

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Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart

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7 January 2021

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7 January 2021

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Myosin isoenzymes in human hypertrophic hearts. Shift in atrial myosin heavy chains and in ventricular myosin light chains

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Transgenic remodeling of the regulatory myosin light chains in the mammalian heart.

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7 January 2021

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7 January 2021

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Structural changes in the actomyosin cross-bridges associated with force generation

7 January 2021

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Evidence for cross-bridge attachment in relaxed muscle at low ionic strength

7 January 2021

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7 January 2021

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ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle

7 January 2021

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7 January 2021

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7 January 2021

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Force-velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle

7 January 2021

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7 January 2021

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Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle

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7 January 2021

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Modulation of crossbridge kinetics by myosin isoenzymes in skinned human heart fibers

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Enhanced force generation by smooth muscle myosin in vitro

7 January 2021

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Maximum speed of shortening and ATPase activity in atrial and ventricular myocardia of hyperthyroid rats

7 January 2021

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The failing human heart is unable to use the Frank-Starling mechanism

7 January 2021

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Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot

7 January 2021

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Regulation of human heart contractility by essential myosin light chain isoforms

7 January 2021

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Skeletal muscle myosin light chains are essential for physiological speeds of shortening.

7 January 2021

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Binding of the amino-terminal region of myosin alkali 1 light chain to actin and its effect on actin-myosin interaction

7 January 2021

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The widespread distribution of alpha-N-trimethylalanine as the N-terminal amino acid of light chains from vertebrate striated muscle myosins

7 January 2021

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Different actin affinities of human cardiac essential myosin light chain isoforms

7 January 2021

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Myosin light chain-actin interaction regulates cardiac contractility.

7 January 2021

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An essential myosin light chain peptide induces supramaximal stimulation of cardiac myofibrillar ATPase activity

7 January 2021

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The structure and function of proline-rich regions in proteins

7 January 2021

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Alterations of excitation-contraction coupling in stunned myocardium and in failing myocardium

7 January 2021

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Increased expression and regional differences of atrial myosin light chain 1 in human ventricles with old myocardial infarction. Analyses using two monoclonal antibodies

7 January 2021

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Novel monoclonal antibodies specific for human cardiac myosin light-chain 1: useful tools for analysis of normal and pathological hearts.

7 January 2021

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Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy

7 January 2021

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Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure

7 January 2021

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Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure

7 January 2021

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Altered myocardial force-frequency relation in human heart failure

7 January 2021

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Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy

7 January 2021

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Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy. Functional evidence for alterations in intracellular Ca2+ handling

7 January 2021

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Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

7 January 2021

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Endothelial cell regulation of contractility of the heart

7 January 2021

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Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand?

7 January 2021

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Hibernating myocardium: a review

7 January 2021

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Only hibernating myocardium invariably shows early recovery after coronary revascularization.

7 January 2021

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The energy expenditure of actomyosin-ATPase, Ca(2+)-ATPase and Na+,K(+)-ATPase in guinea-pig cardiac ventricular muscle

7 January 2021

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Quantification of [Ca2+]i in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion

7 January 2021

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Titins: giant proteins in charge of muscle ultrastructure and elasticity

7 January 2021

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Titin, myosin light chains and C-protein in the developing and failing human heart

7 January 2021

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Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy

7 January 2021

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Altered expression of titin and contractile proteins in failing human myocardium

7 January 2021

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Molecular changes of titin in left ventricular dysfunction as a result of chronic hibernation

7 January 2021

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Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial function

7 January 2021

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Effects of partial extraction of light chain 2 on the Ca2+ sensitivities of isometric tension, stiffness, and velocity of shortening in skinned skeletal muscle fibers

7 January 2021

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The regulatory light chains of myosin modulate cross-bridge cycling in skeletal muscle

7 January 2021

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Role of troponin I proteolysis in the pathogenesis of stunned myocardium

7 January 2021

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Human cardiac troponin T: cloning and expression of new isoforms in the normal and failing heart

7 January 2021

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Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart.

7 January 2021

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Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart.

7 January 2021

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Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Differential expression of slow and fast skeletal muscle troponin C

7 January 2021

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Alpha-skeletal actin is associated with increased contractility in the mouse heart

7 January 2021

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Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts

7 January 2021

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Exchange of beta- for alpha-tropomyosin in hearts of transgenic mice induces changes in thin filament response to Ca2+, strong cross-bridge binding, and protein phosphorylation

7 January 2021

1 reference

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Phosphorylation of cardiac myosin light chain 2 by protein kinase C and myosin light chain kinase increases Ca(2+)-stimulated actomyosin MgATPase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Increased calcium sensitivity of chemically skinned human atria by myosin light chain kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Phosphorylation and thiophosphorylation by myosin light chain kinase: different effects on mechanical properties of chemically skinned ventricular fibers from the pig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Protein kinase C enhances myosin light-chain kinase effects on force development and ATPase activity in rat single skinned cardiac cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Isolation and characterization of the human cardiac troponin I gene (TNNI3)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Bisphosphorylation of cardiac troponin I modulates the Ca(2+)-dependent binding of myosin subfragment S1 to reconstituted thin filaments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Investigation of the effects of phosphorylation of rabbit striated muscle alpha alpha-tropomyosin and rabbit skeletal muscle troponin-T

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Isolation and characterization of tropomyosin kinase from chicken embryo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Troponin I isoforms and differential effects of acidic pH on soleus and cardiac myofilaments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Sarcomere length versus interfilament spacing as determinants of cardiac myofilament Ca2+ sensitivity and Ca2+ binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

The cardiac troponin C isoform and the length dependence of Ca2+ sensitivity of tension in myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Existence of the Frank-Starling mechanism in the failing human heart. Investigations on the organ, tissue, and sarcomere levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Effects of phosphorylation of troponin I and C protein on isometric tension and velocity of unloaded shortening in skinned single cardiac myocytes from rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Gene transfer strategies for augmenting cardiac function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7

Contractile properties of skeletal muscle fibers in relation to myofibrillar protein isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900258-7