Use of isotope effects to elucidate enzyme mechanisms (Q28273181)

CRC critical reviews in biochemistry

Europe PubMed Central

title

Use of isotope effects to elucidate enzyme mechanisms (English)

0 references

author name string

W W Cleland

series ordinal

1

0 references

language of work or name

English

0 references

publication date

1982

0 references

published in

0 references

volume

13

0 references

issue

4

0 references

page(s)

385-428

0 references

cites work

The expression of isotope effects on enzyme-catalyzed reactions

1 reference

https://api.crossref.org/works/10.3109/10409238209108715

Thiohemiacetal formation by inhibitory aldehydes at the active site of papain

20 April 2017

1 reference

https://api.crossref.org/works/10.3109/10409238209108715

Mechanistic studies on the rat kidney flavoenzyme L-α-hydroxy acid oxidase

20 April 2017

1 reference

https://api.crossref.org/works/10.3109/10409238209108715

Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

20 April 2017

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Use of isotope effects to deduce the chemical mechanism of fumarase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Equilibrium carbon isotope effect on a decarboxylation reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Deuterium isotope effects on lactate dehydrogenase using L-2-hydroxysuccinamate and effect of an inhibitor in the variable substrate on observed isotope effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Demonstration of carbonium ion intermediate during lysozyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Equilibrium perturbation by isotope substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Partition analysis and concept of net rate constants as tools in enzyme kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Steady-state analysis of kinetic isotope effects in enzymic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Kinetic and chemical mechanisms of yeast formate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Oxygen-18 leaving group kinetic isotope effects on the hydrolysis of nitrophenyl glycosides. 1. beta-galactosidease-catalyzed hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

The mechanism of action of beta-galactosidase. Effect of aglycone nature and -deuterium substitution on the hydrolysis of aryl galactosides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

The effect of methanol and dioxan on the rates of the β-galactosidase-catalysed hydrolyses of some β-d-galactopyranosides: rate-limiting degalactosylation. The pH-dependence of galactosylation and degalactosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Evidence that hydride transfer precedes proton transfer in the liver alcohol dehydrogenase catalyzed reduction of trans-4-(N,N-dimethylamino)cinnamaldehyde.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Mechanism of hydrogen transfer in the coenzyme B12 dependent dioldehydrase reaction. II

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Aldehyde-Induced Adenosine Triphosphatase Activities of Fructose 6-Phosphate and Fructose Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Isotope effects and structure-reactivity correlations in the yeast alcohol dehydrogenase reaction. A study of the enzyme-catalyzed oxidation of aromatic alcohols

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Mechanism of action of enolase: effect of the beta-hydroxy group on the rate of dissociation of the alpha-carbon-hydrogen bond

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Monovalent cation-induced association of formyltetrahydrofolate synthetase subunits. Solvent isotope effect

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Solvent isotope effect in inorganic pyrophosphatase-catalyzed hydrolysis of inorganic pyrophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Investigation of the catalytic mechanism of yeast inorganic pyrophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid1-3

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10409238209108715