AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis (Q28273478)

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S W Hiebert

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G Grosveld

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J R Downing

Leukaemia/Drosophila homology

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language of work or name

English

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publication date

26 January 1996

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published in

Cell

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volume

84

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page(s)

321-30

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issue

2

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cites work

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Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

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The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal

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The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt

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Dosage requirements for runt in the segmentation of Drosophila embryos.

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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RETRACTED: Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein

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RETRACTED: The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells

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c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer

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The Runt domain identifies a new family of heteromeric transcriptional regulators.

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Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

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The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

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Hematopoietic commitment during embryonic stem cell differentiation in culture

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AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

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Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

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7 January 2021

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

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7 January 2021

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

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Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

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7 January 2021

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

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7 January 2021

Transcription factors and hematopoietic development

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Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

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Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

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A phorbol ester response element within the human T-cell receptor beta-chain enhancer

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Chromosomal translocations in human cancer.

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Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers

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7 January 2021

Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development

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7 January 2021

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

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Transcriptional regulation of interleukin 3 gene expression in T lymphocytes

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Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells

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Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

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7 January 2021

Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity

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7 January 2021

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

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An early haematopoietic defect in mice lacking the transcription factor GATA-2

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Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors

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Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells

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Genetic variability of the murine creatine kinase B gene locus and related pseudogenes in different inbred strains of mice.

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7 January 2021

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

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7 January 2021

The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development

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7 January 2021

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

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Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells

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Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

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7 January 2021

Cooperative binding of Ets-1 and core binding factor to DNA

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7 January 2021

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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7 January 2021

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

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7 January 2021

AML1 is expressed in skeletal muscle and is regulated by innervation

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7 January 2021