New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I (Q28274020)

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Stacey E Patrick

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Aaron Hinken

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Sarah B Scruggs

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Paul Goldspink

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Pieter P de Tombe

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Minae Kobayashi

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Tomoyoshi Kobayashi

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R John Solaro

Biochimica et Biophysica Acta

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language of work or name

English

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publication date

April 2013

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published in

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volume

1833

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issue

4

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page(s)

823-32

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cites work

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Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

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Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

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Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

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Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction

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Structural and functional domains of the troponin complex revealed by limited digestion

20 March 2017

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Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

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Alanine or aspartic acid substitutions at serine23/24 of cardiac troponin I decrease thin filament activation, with no effect on crossbridge detachment kinetics

20 March 2017

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The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes

29 September 2017

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Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex

29 September 2017

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Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

29 September 2017

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The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

29 September 2017

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Role of the acidic N' region of cardiac troponin I in regulating myocardial function

29 September 2017

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29 September 2017

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The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils

29 September 2017

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Rate of tension development in cardiac muscle varies with level of activator calcium

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

2 June 2018

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Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.

2 June 2018

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Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy

27 November 2018

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27 November 2018

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Inorganic phosphate speeds loaded shortening in rat skinned cardiac myocytes

27 November 2018

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12 December 2020

Defining the region of troponin-I that binds to troponin-C

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12 December 2020

Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I

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12 December 2020

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

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12 December 2020