Mechanism of positive allosteric modulators acting on AMPA receptors (Q28274582)

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7 January 2020

title

Mechanism of positive allosteric modulators acting on AMPA receptors (English)

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7 January 2020

1

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7 January 2020

Kathryn M Partin

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7 January 2020

4

Joshua T Dudman

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7 January 2020

author name string

Suzanne Clark

2

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7 January 2020

Autumn M Weeks

3

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7 January 2020

Eric Gouaux

5

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7 January 2020

language of work or name

English

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publication date

1 September 2005

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7 January 2020

published in

Journal of Neuroscience

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7 January 2020

volume

25

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7 January 2020

issue

39

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7 January 2020

page(s)

9027-9036

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The glutamate receptor ion channels

7 January 2020

cites work

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12 December 2020

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12 December 2020

Experimental assessment of differences between related protein crystal structures

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12 December 2020

Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

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12 December 2020

Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans

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Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

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Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

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The molecular biology of memory storage: a dialogue between genes and synapses

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Mechanism of glutamate receptor desensitization

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Structural mobility of the extracellular ligand-binding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics

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12 December 2020

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

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12 December 2020

Amino-acid residues involved in glutamate receptor 6 kainate receptor gating and desensitization.

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12 December 2020

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

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12 December 2020

Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization.

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12 December 2020

The mechanism of action of aniracetam at synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization

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12 December 2020

Structural basis for partial agonist action at ionotropic glutamate receptors

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12 December 2020

Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.

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12 December 2020

Regulation of AMPA receptor gating by ligand binding core dimers

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Structure and function of glutamate receptor ion channels

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AMPA receptor potentiators for the treatment of CNS disorders

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Raster3D Version 2.0. A program for photorealistic molecular graphics

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AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization.

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Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus

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Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam

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12 December 2020

Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors

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12 December 2020

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Electron-density map interpretation

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12 December 2020

Improved methods for building protein models in electron density maps and the location of errors in these models

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12 December 2020

A family of AMPA-selective glutamate receptors

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12 December 2020

Molecular cloning and functional expression of glutamate receptor subunit genes

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12 December 2020

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

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12 December 2020

A centrally active drug that modulates AMPA receptor gated currents

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12 December 2020

Effects of a memory-enhancing drug on DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents and synaptic transmission in hippocampus

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12 December 2020

PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules

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12 December 2020

AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.

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12 December 2020

Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics

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12 December 2020

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

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12 December 2020

Enhancement by an ampakine of memory encoding in humans.

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12 December 2020

Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli: application of a novel protein folding screen

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12 December 2020

The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization

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12 December 2020

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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12 December 2020

10.1523/JNEUROSCI.2567-05.2005

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

5115017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192394%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

5115017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192394%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

16192394

2 references

Consolidated OpenCitations Corpus – April 2017

5115017