Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia (Q28275381)

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English	Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia	scientific article

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Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia (English)

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author name string

Nilana M T Barros

1

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Betty Hoac

2

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Raquel L Neves

3

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William N Addison

4

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Diego M Assis

5

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Monzur Murshed

6

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Adriana K Carmona

7

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Marc D McKee

8

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publication date

March 2013

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Journal of Bone and Mineral Research

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28

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3

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688-99

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A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

X-linked hypophosphataemia: a homologous disorder in humans and mice

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Novel regulators of Fgf23 expression and mineralization in Hyp bone

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Phex mutation causes overexpression of FGF23 in teeth

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Recent advances in renal phosphate handling

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Post-translational modification and proteolytic processing of urinary osteopontin

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Importance of phosphorylation for osteopontin regulation of biomineralization

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Different forms of DMP1 play distinct roles in mineralization.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Dentin matrix protein-1 isoforms promote differential cell attachment and migration

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

The SCPP gene family and the complexity of hard tissues in vertebrates

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

SCPP gene evolution and the dental mineralization continuum

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Postembedding colloidal-gold immunocytochemistry of noncollagenous extracellular matrix proteins in mineralized tissues

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin and the bone remodeling sequence. Colloidal-gold immunocytochemistry of an interfacial extracellular matrix protein

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

In-gel digestion for mass spectrometric characterization of proteins and proteomes

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Reorganizing the protein space at the Universal Protein Resource (UniProt)

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

A statistical model for identifying proteins by tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Structure and function of disease-causing missense mutations in the PHEX gene

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Phex mutation causes the reduction of npt2b mRNA in teeth.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

ASARM mineralization hypothesis: a bridge to progress

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Phex cDNA cloning from rat bone and studies on phex mRNA expression: tissue-specificity, age-dependency, and regulation by insulin-like growth factor (IGF) I in vivo

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

The Autosomal Dominant Hypophosphatemic Rickets (ADHR) Gene Is a Secreted Polypeptide Overexpressed by Tumors that Cause Phosphate Wasting

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

FGF23 is processed by proprotein convertases but not by PHEX.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Expression and characterization of recombinant osteopontin peptides representing matrix metalloproteinase proteolytic fragments

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Molecular characterisation of the Hyp deletion and an improved assay for its detection

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Defective bone formation by hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Functions of the extracellular matrix and matrix degrading proteases during tumor progression

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Dentin Alteration of Deciduous Teeth in Human Hypophosphatemic Rickets

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1766

21 January 2018

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