Essential role of Stat6 in IL-4 signalling (Q28276199)

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T Tanaka

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W Shi

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M Matsumoto

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M Minami

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S Kashiwamura

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K Nakanishi

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N Yoshida

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T Kishimoto

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S Akira

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

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language of work or name

English

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publication date

18 April 1996

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published in

Nature

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volume

380

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page(s)

627-30

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issue

6575

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cites work

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Interleukin 4 signals through two related pathways

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Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins

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An interleukin-4-induced transcription factor: IL-4 Stat

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Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

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Role of IRS-2 in insulin and cytokine signalling

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Generation and analysis of interleukin-4 deficient mice

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Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

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Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

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Lymphokine control of in vivo immunoglobulin isotype selection.

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Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression

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Molecular structure of human lymphocyte receptor for immunoglobulin E

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Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor

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Interleukin-induced increase in Ia expression by normal mouse B cells

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B-cell stimulatory factor 1 activates resting B cells

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B cell stimulatory factor 1 (BSF-1) prepares resting B cells to enter S phase in response to anti-IgM and lipopolysaccharide

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B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes

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Interleukin 4 targeting of immunoglobulin heavy chain class-switch recombination

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Interleukin 4 receptor: signaling mechanisms

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The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

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IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

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Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

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Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

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