TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes (Q28276964)

1

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Xiaoli Zhang

2

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Xian-Ping Dong

3

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Mohammad Samie

4

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Xinran Li

5

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Xiping Cheng

6

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Andrew Goschka

7

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Dongbiao Shen

8

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Yandong Zhou

9

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Janice Harlow

10

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Michael X Zhu

11

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Dejian Ren

13

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Haoxing Xu

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

14

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language of work or name

English

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publication date

12 October 2012

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published in

Cell

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volume

151

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page(s)

372-83

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issue

2

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cites work

1 reference

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An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

20 March 2017

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TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

20 March 2017

1 reference

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Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

20 March 2017

1 reference

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Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

20 March 2017

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Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

20 March 2017

1 reference

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NAADP mobilizes calcium from acidic organelles through two-pore channels

20 March 2017

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Identification of a chemical probe for NAADP by virtual screening

20 March 2017

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Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

20 March 2017

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Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

20 March 2017

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The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores

20 March 2017

1 reference

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The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis

20 March 2017

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PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

6 April 2017

1 reference

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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

7 April 2017

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Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes

29 September 2017

1 reference

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Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

29 September 2017

1 reference

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Small molecule activators of TRPML3

29 September 2017

1 reference

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TRP channels of intracellular membranes

29 September 2017

1 reference

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Second messenger signaling: multiple receptors for NAADP.

29 September 2017

1 reference

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TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

29 September 2017

1 reference

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Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

29 September 2017

1 reference

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Transient receptor potential channels meet phosphoinositides

29 September 2017

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PIP2 is a necessary cofactor for ion channel function: how and why?

29 September 2017

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Two newly identified genetic determinants of pigmentation in Europeans

29 September 2017

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Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475186

The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475186

Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells

29 September 2017

1 reference

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Development of analytical procedures for determination of total chromium by quadrupole ICP-MS and high-resolution ICP-MS, and hexavalent chromium by HPLC-ICP-MS, in different materials used in the automotive industry

29 September 2017

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Autoreceptors, membrane potential and the regulation of transmitter release

29 September 2017

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On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

29 September 2017

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The permeability of the sodium channel to metal cations in myelinated nerve

29 September 2017

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Nicotinic acid adenine dinucleotide phosphate analogues containing substituted nicotinic acid: effect of modification on Ca(2+) release

29 September 2017

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Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

2 June 2018

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A cation counterflux supports lysosomal acidification

2 June 2018

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Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

2 June 2018

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The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.

2 June 2018

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Metal ion content of cholinergic synaptic vesicles isolated from the electric organ of Torpedo: effect of stimulation-induced transmitter release

27 November 2018

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12 December 2020

Effect of calcium chelation on the ion content of liver mitochondria in carbon tetrachloride-poisoned rats

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12 December 2020

Frequent fusion of liposomes to a positively charged planar bilayer without calcium ions

1 reference

12 December 2020

Monovalent cations differentially affect membrane surface properties and membrane curvature, as revealed by fluorescent probes and dynamic light scattering

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12 December 2020

10.1016/J.CELL.2012.08.036

Identifiers

DOI

1 reference

349399

349399

1 reference

1 reference

1 reference