Colorectal cancer and genetic alterations in the Wnt pathway (Q28276998)

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Europe PubMed Central

title

Colorectal cancer and genetic alterations in the Wnt pathway (English)

0 references

1 reference

1 reference

2

I Tomlinson

0 references

author name string

S Segditsas

series ordinal

1

0 references

language of work or name

English

0 references

publication date

4 December 2006

0 references

published in

Oncogene

0 references

volume

25

0 references

issue

57

0 references

page(s)

7531-7

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

The Wnt antagonist sFRP1 in colorectal tumorigenesis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210059

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Familial Adenomatous Polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Beta-catenin mutations in cell lines established from human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Attenuated familial adenomatous polyposis (AFAP). A review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Phenotypic expression in familial adenomatous polyposis: partial prediction by mutation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Truncated APC is required for cell proliferation and DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Alleles of the APC gene: an attenuated form of familial polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

APC gene: database of germline and somatic mutations in human tumors and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210059

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210059

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1844100

1001619578

0 references

Fatcat ID

release_grkqml6o6bfjtpriwtgmszdpku

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/grkqml6o6bfjtpriwtgmszdpku

mapped directly with Wikidata item

24 November 2022

based on heuristic

1844100

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference