Tetraspanin functions and associated microdomains (Q28284176)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Tetraspanin functions and associated microdomains (English)

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author name string

Martin E Hemler

series ordinal

1

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language of work or name

English

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publication date

October 2005

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published in

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volume

6

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page(s)

801-11

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issue

10

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cites work

CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system

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CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

21 April 2017

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A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58

21 April 2017

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The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes

21 April 2017

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Characterization of mice lacking the tetraspanin superfamily member CD151

21 April 2017

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Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions

21 April 2017

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The gamete fusion process is defective in eggs of Cd9-deficient mice

21 April 2017

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Severely reduced female fertility in CD9-deficient mice

21 April 2017

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Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation

21 April 2017

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Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis

21 April 2017

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Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions

21 April 2017

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PDZ domains: structural modules for protein complex assembly

21 April 2017

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EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily

21 April 2017

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EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5

21 April 2017

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Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells

21 April 2017

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

21 April 2017

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Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance

21 April 2017

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Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway

21 April 2017

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 April 2017

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EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells

21 April 2017

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Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

21 April 2017

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The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity

21 April 2017

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Palmitoylation of intracellular signaling proteins: regulation and function

21 April 2017

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Specific tetraspanin functions

21 April 2017

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Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

21 April 2017

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Functions of lipid rafts in biological membranes

21 April 2017

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Tetraspanins: molecular organisers of the leukocyte surface

21 April 2017

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Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

31 March 2020

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31 March 2020

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The tetraspanin superfamily in insects

31 March 2020

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Structure of the Tetraspanin Main Extracellular Domain

31 March 2020

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A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.

31 March 2020

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The role of the peripherin/RDS gene in retinal dystrophies

31 March 2020

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CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.

31 March 2020

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Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions

31 March 2020

1 reference

Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration

31 March 2020

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An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology

31 March 2020

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A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia

31 March 2020

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α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane

31 March 2020

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Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse

31 March 2020

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Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis.

31 March 2020

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The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function.

31 March 2020

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Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening

31 March 2020

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Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.

31 March 2020

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A regulatory role for CD37 in T cell proliferation

31 March 2020

1 reference

The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses

31 March 2020

1 reference

Normal lymphocyte development but delayed humoral immune response in CD81-null mice

31 March 2020

1 reference

Tetraspanin microdomains in immune cell signalling and malignant disease.

31 March 2020

1 reference

The tetraspanin web modulates immune-signalling complexes

31 March 2020

1 reference

Requirement of CD9 on the egg plasma membrane for fertilization.

31 March 2020

1 reference

Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice

31 March 2020

1 reference

Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes

31 March 2020

1 reference

Cell surface monkey CD9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity

31 March 2020

1 reference

Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.

31 March 2020

1 reference

A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation

31 March 2020

1 reference

Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse

31 March 2020

1 reference

A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen.

31 March 2020

1 reference

Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.

31 March 2020

1 reference

Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes

31 March 2020

1 reference

PLS1, a gene encoding a tetraspanin-like protein, is required for penetration of rice leaf by the fungal pathogen Magnaporthe grisea

31 March 2020

1 reference

The tetraspanin BcPls1 is required for appressorium-mediated penetration of Botrytis cinerea into host plant leaves.

31 March 2020

1 reference

A new class of tetraspanins in fungi.

31 March 2020

1 reference

Integrin associated proteins

31 March 2020

1 reference

The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.

31 March 2020

1 reference

Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling

31 March 2020

1 reference

Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation

31 March 2020

1 reference

Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins

31 March 2020

1 reference

Protein kinase C and the cytoskeleton.

31 March 2020

1 reference

EWI-2 modulates lymphocyte integrin alpha4beta1 functions

31 March 2020

1 reference

Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

31 March 2020

1 reference

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins

31 March 2020

1 reference

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

31 March 2020

1 reference

CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells

31 March 2020

1 reference

A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase

31 March 2020

1 reference

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

31 March 2020

1 reference

CD151 regulates epithelial cell–cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization

31 March 2020

1 reference

The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras.

31 March 2020

1 reference

KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

31 March 2020

1 reference

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

31 March 2020

1 reference

Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration

31 March 2020

1 reference

Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR.

31 March 2020

1 reference

Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking

31 March 2020

1 reference

Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography

31 March 2020

1 reference

Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology

31 March 2020

1 reference

Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling

31 March 2020

1 reference

CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner

31 March 2020

1 reference

Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation

31 March 2020

1 reference

Palmitoylation supports assembly and function of integrin-tetraspanin complexes

31 March 2020

1 reference

Compartmentalization of integrin α6β4 signaling in lipid rafts

31 March 2020

1 reference

Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cells

31 March 2020

1 reference

A physical and functional link between cholesterol and tetraspanins

31 March 2020

1 reference

Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).

31 March 2020

1 reference

The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts

31 March 2020

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B cell signaling is regulated by induced palmitoylation of CD81.

31 March 2020

1 reference

Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts

31 March 2020

1 reference

Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes

31 March 2020

1 reference

Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

31 March 2020

1 reference

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

31 March 2020

1 reference

Functional domains in tetraspanin proteins

31 March 2020

1 reference

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor

31 March 2020

1 reference

The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation

31 March 2020

1 reference

Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci

31 March 2020

1 reference

Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice

31 March 2020

1 reference

Increased brain size and glial cell number in CD81-null mice

31 March 2020

1 reference

Tetraspanins and malignancy

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion

1 reference