APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations (Q28284341)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

ectrodactyly–ectodermal dysplasia–cleft syndrome

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Simon J van Heeringen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Hans van Bokhoven

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Klas Wiman

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Jinfeng Shen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Ellen H van den Bogaard

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Evelyn N Kouwenhoven

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Vladimir J N Bykov

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Tuula Rinne

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Qiang Zhang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Geuranne S Tjabringa

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Joost Schalkwijk

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Huiqing Zhou

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

language of work or name

English

0 references

publication date

25 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

110

1 reference

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22 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

2157-2162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

An integrated encyclopedia of DNA elements in the human genome

22 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Rapp-Hodgkin and Hay-Wells ectodermal dysplasia syndromes represent a variable spectrum of the same genetic disorder

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63 is the molecular switch for initiation of an epithelial stratification program

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63 is a p53 homologue required for limb and epidermal morphogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63, a story of mice and men.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Cytoplasmic functions of the tumour suppressor p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Claudin-1 is a p63 target gene with a crucial role in epithelial development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Restoration of p53 to limit tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Shaping genetic alterations in human cancer: the p53 mutation paradigm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

TAp63 and DeltaNp63 in cancer and epidermal development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63-associated disorders.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

P53 and prognosis: new insights and further complexity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

p63 and the epithelial stem cell: more than status quo?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568378

A dominant-negative form of p63 is required for epidermal proliferation in zebrafish.

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1201993110

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23355676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pattern of p63 mutations and their phenotypes--update

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23355676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Embryonic stem cells as an ectodermal cellular model of human p63-related dysplasia syndromes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23355676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1201993110

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

ADS bibcode

2013PNAS..110.2157S

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23355676%20AND%20SRC:MED&resulttype=core&format=json