The same gamma-secretase accounts for the multiple intramembrane cleavages of APP (Q28284426)

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24 December 2019

title

The same gamma-secretase accounts for the multiple intramembrane cleavages of APP (English)

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24 December 2019

4

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24 December 2019

Xuemin Xu

5

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24 December 2019

author name string

Guojun Zhao

1

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24 December 2019

Jianxin Tan

2

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24 December 2019

Guozhang Mao

3

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24 December 2019

language of work or name

English

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publication date

11 January 2007

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Journal of Neurochemistry

24 December 2019

published in

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24 December 2019

volume

100

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24 December 2019

issue

5

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24 December 2019

page(s)

1234-1246

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

24 December 2019

cites work

1 reference

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

21 January 2018

1 reference

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Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

1 reference

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

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Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

21 January 2018

1 reference

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New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

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Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease

21 January 2018

1 reference

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

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Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

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Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

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Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04302.X

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04302.X

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

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10.1111/J.1471-4159.2006.04302.X

21 January 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

3926874

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24 December 2019

3926874

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3926874