Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2 (Q28284529)

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English	Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2	scientific article

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scholarly article

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Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2 (English)

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author name string

S J McCallum

1

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W J Wu

2

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R A Cerione

3

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language of work or name

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publication date

6 September 1996

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Journal of Biological Chemistry

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271

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36

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21732-7

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Development of cell polarity in budding yeast

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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The Dbl family of oncogenes

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A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs

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GAPs for rho-related GTPases

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p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking

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Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets

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Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42

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The effector interactions of p21ras

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

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The Ras-related GTPase Rac1 binds tubulin

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Multiple Ras functions can contribute to mammalian cell transformation

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

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Identifiers

10.1074/JBC.271.36.21732

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