Treatment of opioid-induced gut dysfunction (Q28284578)

Expert Opinion on Investigational Drugs

Europe PubMed Central

title

Treatment of opioid-induced gut dysfunction (English)

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Peter Holzer

1

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language of work or name

English

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publication date

February 2007

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published in

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volume

16

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issue

2

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page(s)

181-94

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cites work

Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

Oral methylnaltrexone for opioid-induced constipation

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543784.16.2.181

Opioid-induced bowel dysfunction: pathophysiology and potential new therapies

21 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Insights into opioid action in the intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Alvimopan, a selective peripherally acting mu-opioid antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

The role of endogenous opioids in the control of gastrointestinal motility: predictions from in vitro modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

The opioid system in the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Neurochemical classification of myenteric neurons in the guinea-pig ileum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Types of neurons in the enteric nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Function of opioids in the enteric nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Sites of action of morphine on the ascending excitatory reflex in the guinea-pig small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Endogenous nitric oxide modulates morphine-induced constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Morphine contracts the guinea pig ileal circular muscle by interfering with a nitric oxide mediated tonic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Mu, but not kappa, opioid agonists induce contractions of the canine small intestine ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effects of the prodrug loperamide oxide, loperamide, and placebo on jejunal motor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Regulatory role of enteric kappa opioid receptors in human colonic motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Release of dynorphin, somatostatin and substance P from the vascularly perfused small intestine of the guinea-pig during peristalsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of mu and kappa opioid receptor blockade and of chronic sympathetic denervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Identification of two related pentapeptides from the brain with potent opiate agonist activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Unexpected reversal effects of naloxone on the guinea pig ileum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

In vitro evidence for the participation of intestinal opioids in the control of peristalsis in the guinea pig small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Opioids modulate periodicity rather than efficacy of peristaltic waves in the guinea pig ileum in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effects of mu- and kappa-opioid receptors on postoperative ileus in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effect of surgical stress on endogenous morphine and cytokine levels in the plasma after laparoscopoic or open cholecystectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Naloxone treatment for irritable bowel syndrome--a randomized controlled trial with an oral formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Is ganglionic transmission through nicotinic receptors essential for the peristaltic reflex in the guinea-pig ileum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Stimulant action of pituitary adenylate cyclase-activating peptide on normal and drug-compromised peristalsis in the guinea-pig intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

The central and peripheral influences of opioids on gastrointestinal propulsion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Racecadotril: a new approach to the treatment of diarrhoea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Racecadotril in the treatment of acute watery diarrhea in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

A review of the potential role of methylnaltrexone in opioid bowel dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Gut motility and transit changes in patients receiving long-term methadone maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Mechanisms and treatment of postoperative ileus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Mechanisms of postoperative ileus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Management of opioid-induced gastrointestinal effects in patients receiving palliative care

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Basic and clinical pharmacology of new motility promoting agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Long-term treatment of cancer pain with transdermal fentanyl

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Preclinical studies of opioids and opioid antagonists on gastrointestinal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Oral naloxone reduces constipation but not antinociception from oral morphine in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Oral naloxone reverses opioid-associated constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Assessment of nalmefene glucuronide as a selective gut opioid antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Opioid-induced delay in gastric emptying: a peripheral mechanism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Alvimopan for the management of postoperative ileus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction--a 21-day treatment-randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Selective postoperative inhibition of gastrointestinal opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

Alvimopan∗∗Alvimopan is the official USAN name adopted as of press time. (ADL 8-2698) Is a Novel Peripheral Opioid Antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.2.181

10.1517/13543784.16.2.181

21 January 2018

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

799522

Fatcat ID

release_zddtxvt3vvcspnehknwxxy6n6u

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Fatcat

https://api.fatcat.wiki/v0/release/zddtxvt3vvcspnehknwxxy6n6u

mapped directly with Wikidata item

24 November 2022

based on heuristic

OpenCitations bibliographic resource ID

799522

1 reference