A genome-wide association study identifies novel risk loci for type 2 diabetes (Q28287727)

22

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Marc Prentki

17

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Beverley Balkau

11

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Christian Dina

4

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Thomas J. Hudson

Thomas J Hudson

14

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Robert Sladek

Robert Sladek

1

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Barbara Heude

Barbara Heude

12

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David J. Balding

David J Balding

19

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Constantin Polychronakos

Constantin Polychronakos

21

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David Meyre

20

David Meyre

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Alexey V Pshezhetsky

16

Alexey V Pshezhetsky

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author name string

Ghislain Rocheleau

2

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Johan Rung

3

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Lishuang Shen

5

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David Serre

6

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Philippe Boutin

7

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Daniel Vincent

8

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Alexandre Belisle

9

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Samy Hadjadj

10

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Guillaume Charpentier

13

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Barry I Posner

describes a project that uses

18

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language of work or name

English

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publication date

22 February 2007

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published in

Nature

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volume

445

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page(s)

881-5

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issue

7130

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genome-wide association study

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Genetic epidemiology of diabetes

inferred from title

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

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A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

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Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

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Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

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Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

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Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

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Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

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TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

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Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

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A fat attack occurred in fat city.

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Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis

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Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

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Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information

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A haplotype map of the human genome

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Demonstrating stratification in a European American population

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In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

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Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans

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A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study

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A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

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Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

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Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

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Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex.

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An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures

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Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility

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Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study

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Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

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Hedgehog signaling regulation of insulin production by pancreatic beta-cells

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Genetic interaction between Lef1 and Alx4 is required for early embryonic development.

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An evolutionary framework for common diseases: the ancestral-susceptibility model

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Are rare variants responsible for susceptibility to complex diseases?

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A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels

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The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

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From genotypes to genes: doubling the sample size

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Population structure, differential bias and genomic control in a large-scale, case-control association study

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Genomic control for association studies

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Detecting association in a case-control study while correcting for population stratification

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Case-control association tests correcting for population stratification

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Identifiers

DOI

10.1038/NATURE05616

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

188007

1022931325

0 references

188007

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference