Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation (Q28288372)

Delayed thymocyte development induced by augmented expression of p56lck

Europe PubMed Central

title

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation (English)

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2

Arthur Weiss

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author name string

Emil H Palacios

series ordinal

1

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language of work or name

English

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publication date

18 October 2004

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published in

Oncogene

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volume

23

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issue

48

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page(s)

7990-8000

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Thymic tumorigenesis induced by overexpression of p56lck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Location is everything: lipid rafts and immune cell signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Unc119, a novel activator of Lck/Fyn, is essential for T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

CD45: a critical regulator of signaling thresholds in immune cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Genetic and biochemical studies of protein N-myristoylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Proximal protein tyrosine kinases in immunoreceptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Receptors and signals in early thymic selection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

No requirement for p56lck in the antigen-stimulated clonal deletion of thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Antigen receptor tail clue.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Different initiation of pre-TCR and gammadeltaTCR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Csk controls antigen receptor-mediated development and selection of T-lineage cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Selection of the T cell repertoire.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

TCR signals mediated by Src family kinases are essential for the survival of naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Early T lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Structures of Src-family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

LAT links the pre-BCR to calcium signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Essential role of LAT in T cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208074

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208074

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

2238692

1041178246

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2238692

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference