Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity (Q28291642)

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E R Urquhart

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S K Gillespie

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D V Levengood

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D D Ginty

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A L Kolodkin

The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing

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language of work or name

English

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publication date

November 1998

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published in

Neuron

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volume

21

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issue

5

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page(s)

1079-92

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cites work

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Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III

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Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ.

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Neuropilin is a receptor for the axonal chemorepellent Semaphorin III

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Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system.

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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice.

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The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization

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A role for collapsin-1 in olfactory and cranial sensory axon guidance.

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Steering clear of semaphorins: neuropilins sound the retreat

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Neuropilin is a semaphorin III receptor

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Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity.

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A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members

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The neuronal cell-adhesion molecule axonin-1 is specifically released by an endogenous glycosylphosphatidylinositol-specific phospholipase.

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Cysteine mutations in the MAM domain result in monomeric meprin and alter stability and activity of the proteinase

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Patterning neuronal connections by chemorepulsion: the semaphorins

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Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord.

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Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns

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Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.

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The molecular biology of axon guidance

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

3099714

3099714

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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