EpCAM in carcinogenesis: the good, the bad or the ugly (Q28293163)

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Lieuwe J Melchers

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Marcel H J Ruiters

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Lou F M H de Leij

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Pamela M J McLaughlin

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Marianne G Rots

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies

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language of work or name

English

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publication date

November 2010

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published in

Carcinogenesis

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volume

31

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issue

11

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page(s)

1913-21

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cites work

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Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival

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Decreased expression of Ep-CAM protein is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan.

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Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer

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The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation

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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy

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EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

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Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy

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Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

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A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression

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Identification of pancreatic cancer stem cells

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Prospective identification of tumorigenic breast cancer cells

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Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma

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EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis

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Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma

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The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung

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Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers.

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Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer.

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Expression patterns of potential therapeutic targets in prostate cancer.

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Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker

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Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer.

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Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer.

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Overexpression of epithelial cell adhesion molecule in primary, metastatic, and recurrent/chemotherapy-resistant epithelial ovarian cancer: implications for epithelial cell adhesion molecule-specific immunotherapy.

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DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression

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Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation

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EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer

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Identification of EpCAM as the gene for congenital tufting enteropathy

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Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines

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The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context

21 January 2018

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Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion

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Epigenetics in cancer

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DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene

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Chromatin modifications and their function

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Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities

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Zinc-finger-based artificial transcription factors and their applications

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The triple helix: 50 years later, the outcome

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Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment

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Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule

21 January 2018

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Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

21 January 2018

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The emerging role of EpCAM in cancer and stem cell signaling

21 January 2018

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Catumaxomab--trifunctional anti-EpCAM antibody used to treat malignant ascites

21 January 2018

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