Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake (Q28293369)

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English	Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake	scientific article

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Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake (English)

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Graziano Pinna

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Erminio Costa

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Alessandro Guidotti

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publication date

June 2006

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Psychopharmacology

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186

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3

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362-72

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Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain

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Neurosteroidogenesis: relevance to neurosteroid actions in brain and modulation by psychotropic drugs

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Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis

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Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

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Selective serotonin reuptake inhibitors for premenstrual dysphoric disorder: the emerging gold standard?

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Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

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Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

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In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

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12 December 2020

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Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.

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12 December 2020

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Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior

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12 December 2020

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GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid

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12 December 2020

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Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice

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12 December 2020

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Selective versus multi-transmitter antidepressants: are two mechanisms better than one?

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12 December 2020

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

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12 December 2020

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Neurosteroids in depression: a review

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12 December 2020

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Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

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12 December 2020

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Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in pentobarbital sleep

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12 December 2020

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Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

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12 December 2020

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From monoamines to genomic targets: a paradigm shift for drug discovery in depression

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12 December 2020

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Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice.

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12 December 2020

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The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5α-dihydroprogesterone in psychiatric disorders

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12 December 2020

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Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

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12 December 2020

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GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs

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12 December 2020

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Neuroactive steroids and anxiety disorders.

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12 December 2020

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Psychopharmacology of Aggression: an Overview

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12 December 2020

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How antidepressants help depression: mechanisms of action and clinical response

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12 December 2020

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The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments

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12 December 2020

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History and evolution of the monoamine hypothesis of depression.

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12 December 2020

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2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)

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12 December 2020

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Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

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12 December 2020

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Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself

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12 December 2020

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The dual-action hypothesis: does pharmacology matter?

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12 December 2020

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Clinical pharmacokinetics of fluoxetine

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12 December 2020

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Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

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12 December 2020

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Neuroactive steroids

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12 December 2020

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Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.

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12 December 2020

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Anxiolytic activity of progesterone in progesterone receptor knockout mice.

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12 December 2020

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Benzodiazepines on trial: a research strategy for their rehabilitation

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12 December 2020

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Chronic stress and social housing differentially affect neurogenesis in male and female rats

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12 December 2020

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Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats.

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12 December 2020

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Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group.

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https://pubmed.ncbi.nlm.nih.gov/16432684

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Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function

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12 December 2020

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Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine

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12 December 2020

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Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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The biochemistry of affective disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Current advances and trends in the treatment of depression

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12 December 2020

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Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids: endogenous regulators of the GABA(A) receptor

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids act on recombinant human GABAA receptors

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase.

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Brain allopregnanolone regulates the potency of the GABAA receptor agonist muscimol

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat.

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Structure-activity relationships in steroidal anaesthetics

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Neurosteroids and neuroactive drugs in mental disorders

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Tianeptine, a selective enhancer of serotonin uptake in rat brain

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Neurobiology of depression

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Stress and neuroactive steroids

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Alprazolam dependence prevented by substituting with the beta-carboline abecarnil

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Developments in the drug treatment of panic disorder: what is the place of the selective serotonin reuptake inhibitors?

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Serotonin and its place in the pathogenesis of depression

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Neurosteroids: beginning of the story

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Is mood chemistry?

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis.

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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The role of fluoxetine in the treatment of premenstrual dysphoric disorder

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine and seizures

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Anticonvulsant effect of fluoxetine in humans

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Steroids, neuroactive steroids and neurosteroids in psychopathology

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premenstrual dysphoria and the serotonin system: pathophysiology and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid modulation of GABAA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain neurosteroids in gender-related aggression induced by social isolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the putative physiological role of allopregnanolone on GABA(A) receptor function

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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10.1007/S00213-005-0213-2

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