Molecular genetics of the human cytochrome P450 monooxygenase superfamily (Q28293994)

Biochemistry and molecular biology of the human CYP2C subfamily

Europe PubMed Central

title

Molecular genetics of the human cytochrome P450 monooxygenase superfamily (English)

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G Smith

1

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M J Stubbins

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2

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L W Harries

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3

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C R Wolf

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4

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language of work or name

English

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publication date

December 1998

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published in

Xenobiotica

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volume

28

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issue

12

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page(s)

1129-65

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cites work

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Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

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Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs

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In vitro binding and functional studies comparing the human CYP1A1 negative regulatory element with the orthologous sequences from rodent genes

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Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor

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Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

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Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization

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Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.

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A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

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A novel CYP1A1 gene polymorphism in African-Americans.

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Expression and alternative splicing of the cytochrome P-450 CYP2A7

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Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

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Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver

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cDNA sequence, deduced amino acid sequence, predicted gene structure and chemical regulation of mouse Cyp2e1

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Identification of the primary gene defect at the cytochrome P450 CYP2D locus

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Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

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Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

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Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

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Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions

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Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression

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Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism

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Comparative metabolism of benzo[a]pyrene and drugs in human liver

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Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases

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The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene

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Regional mapping of short tandem repeats on human chromosome 10: cytochrome P450 gene CYP2E, D10S196, D10S220, and D10S225.

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Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

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Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

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Cloning and characterization of the human thromboxane synthase gene promoter

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Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

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4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis

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Polymorphic hydroxylation of Debrisoquine in man.

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Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues

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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

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Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4

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Cytochrome P450 CYP3A5 in the human anterior pituitary gland

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Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

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A screening test for slow metabolisers of tolbutamide

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Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

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Isolation and sequence of a human cytochrome P-450 cDNA clone

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Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene.

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Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene

21 January 2018

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Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

21 January 2018

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Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

21 January 2018

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A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

21 January 2018

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Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts

21 January 2018

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1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

21 January 2018

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The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

21 January 2018

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Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

21 January 2018

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Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

21 January 2018

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S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

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The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

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Molecular genetics of congenital adrenal hyperplasia

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Genetic polymorphism of S-mephenytoin hydroxylation

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cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)

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