Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome (Q28297967)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21062863%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome (English)

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16 January 2020

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4

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16 January 2020

author name string

Jennifer J Hofmann

1

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16 January 2020

Ann C Zovein

2

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16 January 2020

Huilin Koh

3

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16 January 2020

Gerry Weinmaster

5

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16 January 2020

M Luisa Iruela-Arispe

6

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16 January 2020

language of work or name

English

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publication date

1 December 2010

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16 January 2020

number of pages

12

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inferred from page(s)

published in

Development

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16 January 2020

volume

137

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16 January 2020

issue

23

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16 January 2020

page(s)

4061-4072

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Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

16 January 2020

cites work

1 reference

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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

20 March 2017

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The role of notch signaling in the development of intrahepatic bile ducts

20 March 2017

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A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

20 March 2017

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

20 March 2017

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JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype

20 March 2017

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Notch signaling: cell fate control and signal integration in development

20 March 2017

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Generalized lacZ expression with the ROSA26 Cre reporter strain

20 March 2017

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Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

20 March 2017

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

20 March 2017

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

20 March 2017

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Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors

20 March 2017

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Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9

20 March 2017

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Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

20 March 2017

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

20 March 2017

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Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

20 March 2017

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Organogenesis and development of the liver

29 September 2017

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Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism

29 September 2017

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Biliary differentiation and bile duct morphogenesis in development and disease

29 September 2017

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Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis

29 September 2017

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Fate tracing reveals the endothelial origin of hematopoietic stem cells

29 September 2017

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29 September 2017

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The many facets of Notch ligands

29 September 2017

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p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver

29 September 2017

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Notch signaling regulates bile duct morphogenesis in mice

29 September 2017

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Notch signaling in vascular development and physiology

29 September 2017

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Notch signaling in blood vessels: who is talking to whom about what?

29 September 2017

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Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis

29 September 2017

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Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

29 September 2017

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29 September 2017

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Endothelial cells and VEGF in vascular development

29 September 2017

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Endothelial signaling during development

29 September 2017

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Development of the biliary tract

29 September 2017

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Role of endothelial cells in early pancreas and liver development

29 September 2017

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The onecut transcription factor HNF6 is required for normal development of the biliary tract

29 September 2017

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Notch signal transduction: a real rip and more

29 September 2017

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Features of Alagille syndrome in 92 patients: frequency and relation to prognosis

29 September 2017

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Development and differentiation of bile ducts in the mammalian liver

29 September 2017

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29 September 2017

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Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases

29 September 2017

1 reference

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Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.

29 September 2017

1 reference

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Notch signaling controls liver development by regulating biliary differentiation

2 June 2018

1 reference

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Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

2 June 2018

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

2 June 2018

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Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

27 November 2018

1 reference

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Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.

27 November 2018

1 reference

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Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome.

27 November 2018

1 reference

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VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells.

27 November 2018

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Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongation.

27 November 2018

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Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

27 November 2018

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Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

27 November 2018

1 reference

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The role of Notch receptor expression in bile duct development and disease.

27 November 2018

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Notch signaling in development and disease.

27 November 2018

1 reference

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Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development

27 November 2018

1 reference

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Characterization of Notch receptor expression in the developing mammalian heart and liver.

27 November 2018

1 reference

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Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.

27 November 2018

1 reference

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Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

27 November 2018

1 reference

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Liver organogenesis promoted by endothelial cells prior to vascular function.

27 November 2018

1 reference

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Hepatic jagged1 expression studies.

27 November 2018

1 reference

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The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver

27 November 2018

1 reference

12 December 2020

Notch signaling in bile duct development: new insights raise new questions

1 reference

12 December 2020

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice

1 reference

12 December 2020

JAGGED1 gene expression during human embryogenesis elucidates the wide phenotypic spectrum of Alagille syndrome

1 reference

12 December 2020

Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling

1 reference

12 December 2020

Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization

1 reference

12 December 2020

Differentiation of biliary epithelial cells from the mouse hepatic endodermal cells cultured in vitro

1 reference

12 December 2020

Notch, a universal arbiter of cell fate decisions

1 reference

12 December 2020

Identifiers

DOI

10.1242/DEV.052118

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21062863%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21062863%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

21062863

2 references