Rad52 inactivation is synthetically lethal with BRCA2 deficiency (Q28300346)

1

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Shaun P Scott

2

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Wendy Bussen

3

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Girdhar G Sharma

4

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Gongshe Guo

5

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Tej K Pandita

6

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Simon N Powell

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

11 January 2011

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published in

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volume

108

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issue

2

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page(s)

686-91

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cites work

Purified human BRCA2 stimulates RAD51-mediated recombination

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The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

20 March 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

20 March 2017

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Genetic steps of mammalian homologous repair with distinct mutagenic consequences

20 March 2017

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

20 March 2017

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Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

20 March 2017

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Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation

20 March 2017

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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

20 March 2017

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

20 March 2017

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Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

20 March 2017

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Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

20 March 2017

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Stimulation by Rad52 of yeast Rad51-mediated recombination

20 March 2017

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

20 March 2017

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Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae

20 March 2017

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Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells

20 March 2017

1 reference

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Involvement of Brca2 in DNA repair

20 March 2017

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Biallelic inactivation of BRCA2 in Fanconi anemia

20 March 2017

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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

7 April 2017

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Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase

7 April 2017

1 reference

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A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

7 April 2017

1 reference

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

7 April 2017

1 reference

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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

7 April 2017

1 reference

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Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Cellular functions of the BRCA tumour-suppressor proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

MDC1 interacts with Rad51 and facilitates homologous recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Mechanisms of DNA double strand break repair and chromosome aberration formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Coordinated response of mammalian Rad51 and Rad52 to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

DNA recombination: the replication connection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas

29 September 2017

1 reference

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Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

Human Rad52 protein promotes single-strand DNA annealing followed by branch migration

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021033

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010959107

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010959107

Compensatory role for Rad52 during recombinational repair in Ustilago maydis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010959107

BRCA2-dependent and independent formation of RAD51 nuclear foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010959107

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21148102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1010959107

1 reference

ADS bibcode

2011PNAS..108..686F

0 references

1 reference

1 reference

PubMed publication ID

21148102

1 reference