TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity (Q28302170)

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17 January 2020

review article

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title

TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity (English)

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17 January 2020

author name string

Patrick M Lippiello

1

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17 January 2020

Jessica S Beaver

2

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17 January 2020

Gregory J Gatto

3

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17 January 2020

John W James

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17 January 2020

Kristen G Jordan

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17 January 2020

Vincent M Traina

6

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17 January 2020

Jianxun Xie

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17 January 2020

Merouane Bencherif

8

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17 January 2020

language of work or name

English

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publication date

1 January 2008

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CNS Neuroscience & Therapeutics

17 January 2020

published in

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17 January 2020

volume

14

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17 January 2020

issue

4

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17 January 2020

page(s)

266-277

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Acetylcholine and Depression*

17 January 2020

cites work

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Anxiety conditioned to nicotine in the elevated plus-maze is time dependent

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Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function

21 January 2018

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12 December 2020

Effects of chronic treatment with (+)-nicotine on the stress-induced hypertension and downregulation of central nicotinic receptors in rats: comparative study with (-)-nicotine

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12 December 2020

Hypothalamo-pituitary-adrenal cortical responses to low-dose physostigmine and arginine vasopressin administration: sex differences between major depressives and matched control subjects

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12 December 2020

Mecamylamine in Tourette's syndrome: a two-year retrospective case study.

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12 December 2020

Bupropion is a nicotinic antagonist.

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12 December 2020

Comorbid bipolar disorder in Tourette's syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine)

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12 December 2020

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

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12 December 2020

Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.

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12 December 2020

Social isolation modifies nicotine's effects in animal tests of anxiety

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12 December 2020

Mecamylamine: new therapeutic uses and toxicity/risk profile

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12 December 2020

Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat.

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12 December 2020

Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder

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Nicotine induced seizures blocked by mecamylamine and its stereoisomers

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12 December 2020

Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons

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12 December 2020

Anxiolytic effects of mecamylamine in two animal models of anxiety

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12 December 2020

Nicotinic acetylcholine receptors as targets for antidepressants.

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Effect of nicotine and nicotinic receptors on anxiety and depression

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Involvement of prostaglandins in the nicotine-induced pituitary-adrenocortical response during social stress.

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Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors

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12 December 2020

Immunocytochemical localization of the α3, α4, α5, α7, β2, β3 and β4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat

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12 December 2020

Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes

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12 December 2020

Nicotine as a modulator of behavior: beyond the inverted U.

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12 December 2020

Mecamylamine, a new, orally effective, hypotensive agent; experimental and clinical evaluation

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12 December 2020

From brain to blood: alternative splicing evidence for the cholinergic basis of Mammalian stress responses

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12 December 2020

High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation

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12 December 2020

The effects of cholinergic and dopaminergic antagonists on nicotine-induced cerebral neurotransmitter changes

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12 December 2020

Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus

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12 December 2020

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.

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12 December 2020

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice

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12 December 2020

High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs.

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12 December 2020

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice

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12 December 2020

[3H]mecamylamine binding to rat brain membranes. Studies with mecamylamine and nicotine analogues

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12 December 2020

Depression: a new animal model sensitive to antidepressant treatments

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12 December 2020

Drugs and ionic channels: mechanisms and implications

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12 December 2020

Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.

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12 December 2020

Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

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12 December 2020

A novel effect of nicotine on mood and sleep in major depression

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12 December 2020

The neurobiology of depression

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12 December 2020

Response of the hypothalamo-pituitary-adrenal axis to nicotine

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12 December 2020

Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine

1 reference

12 December 2020

10.1111/J.1755-5949.2008.00054.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19040552%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19040552%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

19040552

1 reference