Targeted disruption of the melanocortin-4 receptor results in obesity in mice (Q28302831)

2

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V Fairchild-Huntress

3

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J H Dunmore

4

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Q Fang

5

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L R Berkemeier

6

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W Gu

7

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R A Kesterson

8

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B A Boston

9

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R D Cone

10

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F J Smith

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L A Campfield

12

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P Burn

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F Lee

The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response

14

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language of work or name

English

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publication date

10 January 1997

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published in

Cell

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volume

88

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page(s)

131-41

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issue

1

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cites work

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The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks

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Physiologic observations on yellow obesity in the mouse

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Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.

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Molecular cloning of a novel human melanocortin receptor

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

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Hereditary Obesity and Efficient Food Utilization in Mice

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The age factor in weight of yellow mice; weight reduction of ageing yellows and "thin-yellows" revealed in littermate comparisons

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Neomorphic agouti mutations in obese yellow mice

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Effects of preoptic microinjections of alpha-MSH on fever and normal temperature control in rabbits

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Tackling a weighty problem

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Impairment of Glucose Tolerance in Yellow (Avy/A)(BALB/c × VY) F-l Hybrid Mice by Hyperglycemic Peptide(s) from Human Pituitary Glands*

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7 January 2021

Molecular cloning, expression, and characterization of a fifth melanocortin receptor

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Defective STAT signaling by the leptin receptor in diabetic mice

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7 January 2021

Molecular cloning and characterization of the rat fifth melanocortin receptor

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Weight-reducing effects of the plasma protein encoded by the obese gene

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Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

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7 January 2021

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

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alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain

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7 January 2021

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur

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7 January 2021

Pressor and cardioaccelerator effects of gamma MSH and related peptides

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7 January 2021

Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.

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7 January 2021

Simplified mammalian DNA isolation procedure

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7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

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A gamma-melanocyte stimulating hormone-like peptide causes reflex natriuresis after acute unilateral nephrectomy

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7 January 2021

Central administration of peptides alters thermoregulation in the rabbit

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7 January 2021

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

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Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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7 January 2021

Mechanisms for the pleiotropic effects of the agouti gene

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7 January 2021

The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.

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7 January 2021

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation

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7 January 2021

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage

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7 January 2021

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

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7 January 2021

Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

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7 January 2021

The cloning of a family of genes that encode the melanocortin receptors

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Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone

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The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the rat

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7 January 2021

The opiomelanotropinergic neuronal and endocrine systems

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7 January 2021

Effects of the obese gene product on body weight regulation in ob/ob mice

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7 January 2021

Gene targeting in embryonic stem cells

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7 January 2021

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

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Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system

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7 January 2021

Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation

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7 January 2021

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

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7 January 2021

An extension series in the mouse.

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7 January 2021

Effects of MSH on food intake, body weight and coat color of the yellow obese mouse

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7 January 2021

The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in ob-ob mice.

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7 January 2021

Adipogenesis and obesity: rounding out the big picture

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7 January 2021

The role of neuropeptide Y in the antiobesity action of the obese gene product

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7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

Pancreatic islet cells in preobese yellow Avy/- mice: relation to adult hyperinsulinemia and obesity

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7 January 2021

Evidence for two separate opiate peptide neuronal systems

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7 January 2021

Genetic regulation of plasma corticosterone concentration and its response to castration and allogeneic tumour growth in the mouse

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7 January 2021

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome

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7 January 2021

Body weight and cancer.

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7 January 2021

Lipolysis in genetically obese and diabetes-prone mice.

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7 January 2021

An Analysis of the Relationships Among Obesity, Plasma Insulin, and Hepatic Lipogenic Enzymes in "Viable Yellow Obese" Mice (Avy/a)

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7 January 2021

Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice

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7 January 2021

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene

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7 January 2021

Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice

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7 January 2021

Positional cloning of the mouse obese gene and its human homologue

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7 January 2021