The GTPase superfamily: a conserved switch for diverse cell functions (Q28302983)

Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins

Europe PubMed Central

title

The GTPase superfamily: a conserved switch for diverse cell functions (English)

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author name string

H R Bourne

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1

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D A Sanders

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2

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F McCormick

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3

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language of work or name

English

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publication date

8 November 1990

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published in

Nature

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volume

348

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page(s)

125-32

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issue

6297

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cites work

1 reference

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Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.

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Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

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The role of guanosine 5′-triphosphate in polypeptide chain elongation

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EFTu provides an internal kinetic standard for translational accuracy

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Roles of G protein subunits in transmembrane signalling.

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G proteins: a family of signal transducers

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G proteins control diverse pathways of transmembrane signaling.

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Signal sorting and amplification through G protein-coupled receptors

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Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains

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Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

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Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth

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Topology of signal recognition particle receptor in endoplasmic reticulum membrane.

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ras GTPase activating protein: signal transmitter and signal terminator

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A ras-like protein is required for a post-Golgi event in yeast secretion

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7 January 2021

The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants

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7 January 2021

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

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7 January 2021

Do GTPases direct membrane traffic in secretion?

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7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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7 January 2021

G proteins: transducers of receptor-generated signals

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7 January 2021

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin

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7 January 2021

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit

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Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

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Signals past, present, and future

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Cyclic GMP cascade of vision

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GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

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7 January 2021

The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway.

1 reference

7 January 2021

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins

1 reference

7 January 2021

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1 reference

7 January 2021

The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein

1 reference

7 January 2021

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

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7 January 2021

Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase

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7 January 2021

Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase

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7 January 2021

GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae

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7 January 2021

G-protein subunits. Who carries what message?

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7 January 2021

ras proteins can induce meiosis in Xenopus oocytes

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7 January 2021

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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7 January 2021

Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate).

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7 January 2021

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins.

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7 January 2021

A cytosolic protein catalyzes the release of GDP from p21ras

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7 January 2021

Identification of a nucleotide exchange-promoting activity for p21ras

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7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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7 January 2021

Molecular cloning of two types of GAP complementary DNA from human placenta

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7 January 2021

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.

1 reference

7 January 2021

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects

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7 January 2021

The oncogenic activation of human p21ras by a novel mechanism

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7 January 2021

Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins

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7 January 2021

Genetic analysis of mammalian GAP expressed in yeast.

1 reference

7 January 2021

Suppression of c-ras transformation by GTPase-activating protein

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7 January 2021

Stimulation of p21 ras upon T-cell activation

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7 January 2021

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant

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7 January 2021

ras and GAP--who's controlling whom?

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7 January 2021

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

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7 January 2021

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae

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7 January 2021

Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins

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7 January 2021

Studies of RAS function in the yeast Saccharomyces cerevisiae

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7 January 2021

Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase

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7 January 2021

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

1 reference

7 January 2021

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae

1 reference

7 January 2021

Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.

1 reference

7 January 2021

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1 reference

7 January 2021

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1 reference

7 January 2021

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1 reference

7 January 2021

Binding of GAP to activated PDGF receptors

1 reference

7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

7 January 2021

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

1 reference

7 January 2021

1 reference

7 January 2021

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein

1 reference

7 January 2021

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

7 January 2021

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

1 reference

7 January 2021

The p21 ras C-terminus is required for transformation and membrane association

1 reference

7 January 2021

A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein.

1 reference

7 January 2021

Involvement of GTP-binding "G" proteins in transport through the Golgi stack.

1 reference

7 January 2021

Regulatory role for GTP-binding proteins in endocytosis

1 reference

7 January 2021

Reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex in yeast: the acceptor Golgi compartment is defective in the sec23 mutant

1 reference

7 January 2021

Reconstitution of SEC gene product-dependent intercompartmental protein transport

1 reference

7 January 2021

Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium

1 reference

7 January 2021

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1 reference

7 January 2021

The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast

1 reference

7 January 2021

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1 reference

7 January 2021

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1 reference

7 January 2021

How does the nose know?

1 reference

7 January 2021

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles

1 reference

7 January 2021

Intrasynaptosomal distribution of the ras, rho and smg-25A GTP-binding proteins in bovine brain

1 reference

7 January 2021

Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules

1 reference

7 January 2021

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1 reference

7 January 2021

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1 reference

7 January 2021

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins

1 reference

7 January 2021