DNA-PK: the means to justify the ends? (Q28305446)

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair

Europe PubMed Central

title

DNA-PK: the means to justify the ends? (English)

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author name string

Katheryn Meek

series ordinal

1

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Van Dang

series ordinal

2

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Susan P Lees-Miller

series ordinal

3

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language of work or name

English

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publication date

2008

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published in

Advances in Immunology

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volume

99

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page(s)

33-58

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cites work

1 reference

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7 January 2021

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

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7 January 2021

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

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7 January 2021

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining

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7 January 2021

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

1 reference

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7 January 2021

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

1 reference

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7 January 2021

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

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7 January 2021

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

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7 January 2021

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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7 January 2021

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

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7 January 2021

DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer

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7 January 2021

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

1 reference

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7 January 2021

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

1 reference

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7 January 2021

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

1 reference

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7 January 2021

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

1 reference

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7 January 2021

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

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7 January 2021

Rag mutations reveal robust alternative end joining

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7 January 2021

DNA end-joining: from yeast to man

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7 January 2021

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

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7 January 2021

End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining

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7 January 2021

Synapsis of DNA ends by DNA-dependent protein kinase

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7 January 2021

DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.

1 reference

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7 January 2021

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

1 reference

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7 January 2021

Protein phosphatases regulate DNA-dependent protein kinase activity

1 reference

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7 January 2021

DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

1 reference

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7 January 2021

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

1 reference

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7 January 2021

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Mutations to Ku reveal differences in human somatic cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair

1 reference

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7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

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7 January 2021

The lethality of Ku86 (XRCC5) loss-of-function mutations in human cells is independent of p53 (TP53).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

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7 January 2021

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

1 reference

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7 January 2021

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells.

1 reference

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7 January 2021

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.

1 reference

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7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1 reference

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7 January 2021

Activation of DNA-dependent protein kinase by single-stranded DNA ends

1 reference

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

1 reference

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7 January 2021

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Repair of DNA double strand breaks by non-homologous end joining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Ku86 is essential in human somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Chromosomal double-strand break repair in Ku80-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

1 reference

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7 January 2021

The mechanism of human nonhomologous DNA end joining

1 reference

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7 January 2021

Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Electron microscopy studies on DNA recognition by DNA-PK.

1 reference

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7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

A biochemically defined system for mammalian nonhomologous DNA end joining

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7 January 2021

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

1 reference

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7 January 2021

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

1 reference

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7 January 2021

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

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7 January 2021

SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

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7 January 2021

The DNA-dependent protein kinase: the director at the end.

1 reference

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7 January 2021

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.

1 reference

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7 January 2021

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Polymerase mu is a DNA-directed DNA/RNA polymerase

1 reference

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7 January 2021

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs

1 reference

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7 January 2021

Differential activation of DNA-PK based on DNA strand orientation and sequence bias

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells

1 reference

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7 January 2021

Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Pathways of DNA double-strand break repair during the mammalian cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA-PKcs function regulated specifically by protein phosphatase 5

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The endless tale of non-homologous end-joining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The role of DNA dependent protein kinase in synapsis of DNA ends.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

IgH class switching and translocations use a robust non-classical end-joining pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021

Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0

7 January 2021