The complexity of Raf-1 regulation (Q28305850)

Current Opinion in Cell Biology

Europe PubMed Central

title

The complexity of Raf-1 regulation (English)

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author name string

D K Morrison

series ordinal

1

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R E Cutler

series ordinal

2

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language of work or name

English

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publication date

April 1997

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published in

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volume

9

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page(s)

174-9

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issue

2

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cites work

Raf meets Ras: completing the framework of a signal transduction pathway

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The ins and outs of Raf kinases

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

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Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

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Activation of Raf as a result of recruitment to the plasma membrane

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Equilibrium and kinetic measurements reveal rapidly reversible binding of Ras to Raf.

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7 January 2021

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

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7 January 2021

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

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Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

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Two distinct Raf domains mediate interaction with Ras

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Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

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The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

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7 January 2021

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

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7 January 2021

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase

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7 January 2021

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

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Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf

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Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

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Complex formation between RAS and RAF and other protein kinases

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A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

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14-3-3: modulators of signaling proteins?

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Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

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Activation of Raf-1 by 14-3-3 proteins

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Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

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14-3-3 and its possible role in co-ordinating multiple signalling pathways.

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

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Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

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Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

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Crystal structure of the zeta isoform of the 14-3-3 protein

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Bcr and Raf form a complex in vivo via 14-3-3 proteins.

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14-3-3 proteins associate with cdc25 phosphatases

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7 January 2021

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

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14-3-3 proteins: biological function and domain structure

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

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7 January 2021

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

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7 January 2021

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

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KSR modulates signal propagation within the MAPK cascade

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7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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7 January 2021

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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7 January 2021

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

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7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

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7 January 2021

Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

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7 January 2021

Purification and characterization of an interleukin-1beta-converting enzyme family protease that activates cysteine protease P32 (CPP32)

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7 January 2021

Activation of Raf by ionizing radiation

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7 January 2021

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

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7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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7 January 2021

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2897%2980060-9

7 January 2021

Phosphorylation of Raf by ceramide-activated protein kinase

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https://api.crossref.org/works/10.1016%2FS0955-0674%2897%2980060-9

7 January 2021

Mechanism of inhibition of Raf-1 by protein kinase A.

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7 January 2021

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

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7 January 2021

Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins

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7 January 2021

Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits

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7 January 2021

10.1016/S0955-0674(97)80060-9

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

4812781

4812781

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference